NDLI: Hydroxyapatite nanocrystals as a smart, pH sensitive, delivery system for kiteplatin

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hoeschele, James D. Gandin, Valentina Lelli, Marco Curci, Alessandra Natile, Giovanni Margiotta, Nicola Marzano, Cristina Roveri, Norberto
Description	Author Affiliation: Lelli M ( Bioecoactive S.r.l, via San Donato n.5, 40050 Granarolo, Italy.); Roveri N ( Bioecoactive S.r.l, via San Donato n.5, 40050 Granarolo, Italy.); Marzano C ( Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, 35131, Padova, Italy. valentina.gandina@unipd.it.); Hoeschele JD ( Department of Chemistry, Eastern Michigan University, 48197 Ypsilanti, MI, USA.); Curci A ( Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy. nicola.margiotta@uniba.it.); Margiotta N ( Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy. nicola.margiotta@uniba.it.); Gandin V ( Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, 35131, Padova, Italy. valentina.gandina@unipd.it.); Natile G ( Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy. nicola.margiotta@uniba.it.)
Abstract	Hydroxyapatite (HA) nanocrystals are important inorganic constituents of biological hard tissues in vertebrates and have been proposed as a bone substitute or a coating material for prostheses in biomedicine. Hydroxyapatite is also amenable for its capacity to bind to a great variety of biomolecules and therapeutic agents. As drug carriers, apatite nanoparticles also have the advantage of pH dependent solubility and low toxicity. Thus HA nanoparticles are negligibly soluble at physiological pH but their dissolution is accelerated at lower pH such as that typically found in the vicinity of tumors. In the present study we have investigated the adsorption on and the release from biomimetic HA nanoparticles of two platinum derivatives of cis-1,4-diaminocyclohexane $([PtX_{2}(cis-1,4-DACH)],$ $X_{2}$ = $Cl_{2}$ (1) and 1,1-cyclobutanedicarboxylate (CBDCA, 2)). The first of the two compounds proved to be active against colon cancer cells also resistant to oxaliplatin. The release has been investigated as a function of pH to mimic the different physiological environments of healthy tissues and tumors, and the in vitro cytotoxicity of the releasates from the HA matrices has been assessed against various human cancer cell lines. The results fully confirmed the potential of 1-loaded HA nanoparticles as bone-specific drug delivery devices.
ISSN	14779226
Issue Number	33
Journal	Dalton Trans.
Volume Number	45
e-ISSN	13645447
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-08-16
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Chemistry
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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