NDLI: Investigation of Excess-Electron Transfer in DNA Double-Duplex Systems Allows Estimation of Absolute Excess-Electron Transfer and CPD Cleavage $Rates^{†}$

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Investigation of Excess-Electron Transfer in DNA Double-Duplex Systems Allows Estimation of Absolute Excess-Electron Transfer and CPD Cleavage $Rates^{†}$

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Investigation of Excess-Electron Transfer in DNA Double-Duplex Systems Allows Estimation of Absolute Excess-Electron Transfer and CPD Cleavage $Rates^{†}$

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chatgilialoglu, Chryssostomos Carell, Thomas Fazio, Danila Trindler, Christian Heil, Korbinian
Description	Author Affiliation: Fazio D ( Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, Butenandtstrasse 5-13, Hausâ F, 81377 Munich, Germany.)
Abstract	To investigate the parameters and rates that determine excess-electron transfer processes in DNA duplexes, we developed a DNA double-duplex system containing a reduced and deprotonated flavin donor at the junction of two duplexes with either the same or different electron acceptors in the individual duplex substructures. This model system allows us to bring the two electron acceptors in the duplex substructures into direct competition for injected electrons and this enables us to decipher how the kind of acceptor influences the transfer data. Measurements with the electron acceptors 8-bromo-dA (BrdA), 8-bromo-dG (BrdG), 5-bromo-dU (BrdU), and a cyclobutane pyrimidine dimer, which is a UV-induced DNA lesion, allowed us to obtain directly the maximum overall reaction rates of these acceptors and especially of the TT dimer with the injected electrons in the duplex. In line with previous observations, we detected that the overall dimer cleavage rate is about one order of magnitude slower than the debromination of BrdU. Furthermore, we present a more detailed explanation of why sequence dependence cannot be observed when a TT dimer is used as the acceptor and we estimate the absolute excess-electron hopping rates.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	1
Volume Number	17
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2011-01-03
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	DNA Chemistry Deoxyribonucleosides Chemical Synthesis Flavins Models, Molecular Pyrimidine Dimers Bromodeoxyuridine Circular Dichroism Cyclobutanes DNA Damage DNA Repair Electrons Molecular Structure Sequence Homology, Nucleic Acid Ultraviolet Rays Adverse Effects Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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Investigation of Excess-Electron Transfer in DNA Double-Duplex Systems Allows Estimation of Absolute Excess-Electron Transfer and CPD Cleavage $Rates^{†}$

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