NDLI: The Action of Peroxyl Radicals, Powerful Deleterious Reagents, Explains Why Neither Cholesterol Nor Saturated Fatty Acids Cause Atherogenesis and Age-Related Diseases

Please wait, while we are loading the content...

Year: 2017 Volume: 23

Year: 2016 Volume: 22

Year: 2015 Volume: 21

Year: 2014 Volume: 20

Year: 2014 Volume: 20 Issue: 52

Year: 2014 Volume: 20 Issue: 51

Year: 2014 Volume: 20 Issue: 50

Year: 2014 Volume: 20 Issue: 49

Year: 2014 Volume: 20 Issue: 48

Year: 2014 Volume: 20 Issue: 47

Year: 2014 Volume: 20 Issue: 46

CHR-Insertion (RH, $CH_{3})$ into Cyclohexyl-Substituted Silsesquioxanes: Reactivity and Decomposition Studies

Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials

One-Step Versus Multistep Equilibrium of Carbazole-Bridged Dinuclear Zinc(II) Complex Formation: Metal-Assisted π-Association and -Dissociation Processes

Exploring the Molecular Structure of Imidazolium–Silica-Based Nanoparticle Networks by Combining Solid-State NMR Spectroscopy and First-Principles Calculations

Three-Way Cooperativity in $d^{8}$ Metal Complexes with Ligands Displaying Chemical and Redox Non-Innocence

Selectfluor and NFSI exo-Glycal Fluorination Strategies Applied to the Enhancement of the Binding Affinity of Galactofuranosyltransferase GlfT2 Inhibitors

Nitric Oxide Insertion Reactivity with the Bismuth–Carbon Bond: Formation of the Oximate Anion, $[ON(C_{6}H_{2}tBu_{2}O)]^{−},$ from the Oxyaryl Dianion, $(C_{6}H_{2}tBu_{2}O)^{2−}$

Exchange-Coupled fct-FePd/α-Fe Nanocomposite Magnets Converted from $Pd/Fe_{3}O_{4}$ Core/Shell Nanoparticles

Synthesis of {100} Facet Dominant Anatase $TiO_{2}$ Nanobelts and the Origin of Facet-Dependent Photoreactivity

Catalytic Asymmetric Construction of 3,3′-Spirooxindoles Fused with Seven-Membered Rings by Enantioselective Tandem Reactions

High Performance Photoinitiating Systems for Holography Recording: Need for a Full Control of Primary Processes

Potent Anticancer Activity and Possible Low Toxicity of Platinum(II) Complexes with Functionalized 1,1-Cyclobutanedicarboxylate as a Leaving Ligand

Saturated Red-Light-Emitting Gold(III) Triphenylamine Dendrimers for Solution-Processable Organic Light-Emitting Devices

Efficient Sensing of Explosives by Using Fluorescent Nonporous Films of Oligophenyleneethynylene Derivatives Thanks to Optimal Structure Orientation and Exciton Migration

Recognition of N-Alkyl and N-Aryl Acetamides by N-Alkyl Ammonium Resorcinarene Chlorides

Preferential Formation of SiOC over SiC Linkage upon Thermal Grafting on Hydrogen-Terminated Silicon (111)

Palladium–N-Heterocyclic Carbene (NHC)-Catalyzed Asymmetric Synthesis of Indolines through Regiodivergent $C(sp^{3})H$ Activation: Scope and DFT Study

Stereoselective Total Synthesis and Structural Elucidation of (−)-Indoxamycins A–F

Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity

Thermodynamic and Kinetic Origins of $Au_{25}^{0}$ Nanocluster Electrochemiluminescence

Synthesis and Helical Structures of Poly(ω-alkynamide)s Having Chiral Side Chains: Effect of Solvent on Their Screw-Sense Inversion

Electrochemical Properties of Tin Oxide Flake/Reduced Graphene Oxide/Carbon Composite Powders as Anode Materials for Lithium-Ion Batteries

Density Functional Theory Calculations on Oxidative CC Bond Cleavage and NO Bond Formation of $[Ru^{II}(bpy)_{2}(diamine)]^{2+}$ via Reactive Ruthenium Imide Intermediates

A Combined Metal–Halide/Metal Flux Synthetic Route towards Type-I Clathrates: Crystal Structures and Thermoelectric Properties of $A_{8}Al_{8}Si_{38}$ (A=K, Rb, and Cs)

Cyclooctane Metathesis Catalyzed by Silica-Supported Tungsten Pentamethyl $[(SiO)W(Me)_{5}]:$ Distribution of Macrocyclic Alkanes

Visible-Light-Induced CO Release from a Therapeutically Viable Tryptophan-Derived Manganese(I) Carbonyl (TryptoCORM) Exhibiting Potent Inhibition against E. coli

2-Methoxy-4-methylsulfinylbenzyl: A Backbone Amide Safety-Catch Protecting Group for the Synthesis and Purification of Difficult Peptide Sequences

Ruthenium(II)-Catalyzed Oxidative CH Alkenylations of Sulfonic Acids, Sulfonyl Chlorides and Sulfonamides

Rapid Synthesis of Hollow Ag–Au Nanodendrites in 15 Seconds by Combining Galvanic Replacement and Precursor Reduction Reactions

Multistimuli-Responsive Supramolecular Assembly of Cucurbituril/Cyclodextrin Pairs with an Azobenzene-Containing Bispyridinium Guest

A Well-Defined Monomeric Aluminum Complex as an Efficient and General Catalyst in the Meerwein–Ponndorf–Verley Reduction

Double-Addition Reaction of Aryl Methyl Sulfones with N-tert-Butylsulfinyl Imines: Diastereoselective and Concise Synthesis of 2-Sulfonylated 1,3-Diamines

$MIL-101-SO_{3}H:$ A Highly Efficient Brønsted Acid Catalyst for Heterogeneous Alcoholysis of Epoxides under Ambient Conditions

Development of a Halide-Free Aluminium-Based Catalyst for the Synthesis of Cyclic Carbonates from Epoxides and Carbon Dioxide

A Zinc Phthalocyanine Based Periodic Mesoporous Organosilica Exhibiting Charge Transfer to Fullerenes

Iridium-Catalyst-Based Autonomous Bubble-Propelled Graphene Micromotors with Ultralow Catalyst Loading

Ordered Mesoporous ZSM-5 Employing an Imidazolium-Based Ionic Liquid

A Metal–Organic Framework Containing Unusual Eight-Connected Zr–Oxo Secondary Building Units and Orthogonal Carboxylic Acids for Ultra-sensitive Metal Detection

Mesoporous Silica Particles as Topologically Crosslinking Fillers for Poly(N-isopropylacrylamide) Hydrogels

Pd- and Cu-Catalyzed Stereo- and Regiocontrolled Decarboxylative/CH Fluoroalkenylation of Heteroarenes

One-Step Double Covalent Functionalization of Reduced Graphene Oxide with Xanthates and Peroxides

Heteroaromatic Belts through Fold-in Synthesis: Mechanistic Insights into a Macrocycle-Templated Friedel–Crafts Alkylation

Colorimetric Solvent Indicators Based on Nafion Membranes Incorporating Nickel(II)-Chelate Complexes

The Action of Peroxyl Radicals, Powerful Deleterious Reagents, Explains Why Neither Cholesterol Nor Saturated Fatty Acids Cause Atherogenesis and Age-Related Diseases

Simple Synthetic Receptors for Aspirin

Year: 2014 Volume: 20 Issue: 45

Year: 2014 Volume: 20 Issue: 44

Year: 2014 Volume: 20 Issue: 43

Year: 2014 Volume: 20 Issue: 42

Year: 2014 Volume: 20 Issue: 41

Year: 2014 Volume: 20 Issue: 40

Year: 2014 Volume: 20 Issue: 39

Year: 2014 Volume: 20 Issue: 38

Year: 2014 Volume: 20 Issue: 37

Year: 2014 Volume: 20 Issue: 36

Year: 2014 Volume: 20 Issue: 35

Year: 2014 Volume: 20 Issue: 34

Year: 2014 Volume: 20 Issue: 33

Year: 2014 Volume: 20 Issue: 32

Year: 2014 Volume: 20 Issue: 31

Year: 2014 Volume: 20 Issue: 30

Year: 2014 Volume: 20 Issue: 29

Year: 2014 Volume: 20 Issue: 28

Year: 2014 Volume: 20 Issue: 27

Year: 2014 Volume: 20 Issue: 26

Year: 2014 Volume: 20 Issue: 25

Year: 2014 Volume: 20 Issue: 24

Year: 2014 Volume: 20 Issue: 23

Year: 2014 Volume: 20 Issue: 22

Year: 2014 Volume: 20 Issue: 21

Year: 2014 Volume: 20 Issue: 20

Year: 2014 Volume: 20 Issue: 19

Year: 2014 Volume: 20 Issue: 18

Year: 2014 Volume: 20 Issue: 17

Year: 2014 Volume: 20 Issue: 16

Year: 2014 Volume: 20 Issue: 15

Year: 2014 Volume: 20 Issue: 14

Year: 2014 Volume: 20 Issue: 13

Year: 2014 Volume: 20 Issue: 12

Year: 2014 Volume: 20 Issue: 11

Year: 2014 Volume: 20 Issue: 10

Year: 2014 Volume: 20 Issue: 9

Year: 2014 Volume: 20 Issue: 8

Year: 2014 Volume: 20 Issue: 7

Year: 2014 Volume: 20 Issue: 6

Year: 2014 Volume: 20 Issue: 5

Year: 2014 Volume: 20 Issue: 4

Year: 2014 Volume: 20 Issue: 3

Year: 2014 Volume: 20 Issue: 2

Year: 2014 Volume: 20 Issue: 1

Year: 2013 Volume: 19

Year: 2012 Volume: 18

Year: 2011 Volume: 17

Year: 2010 Volume: 16

Year: 2009 Volume: 15

Year: 2008 Volume: 14

Year: 2007 Volume: 13

Year: 2006 Volume: 12

Year: 2005 Volume: 11

Year: 1997 Volume: 3

The Action of Peroxyl Radicals, Powerful Deleterious Reagents, Explains Why Neither Cholesterol Nor Saturated Fatty Acids Cause Atherogenesis and Age-Related Diseases

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Spiteller, Gerhard Afzal, Mohammad
Description	Author Affiliation: Spiteller G ( University of Bayreuth, Universitätsstr. 30, 95445 Bayreuth (Germany). gerhard.spiteller@uni-bayreuth.de.)
Abstract	Cells respond to alterations in their membrane structure by activating hydrolytic enzymes. Thus, polyunsaturated fatty acids (PUFAs) are liberated. Free PUFAs react with molecular oxygen to give lipid hydroperoxide molecules (LOOHs). In case of severe cell injury, this physiological reaction switches to the generation of lipid peroxide radicals $(LOO^{.}).$ These radicals can attack nearly all biomolecules such as lipids, carbohydrates, proteins, nucleic acids and enzymes, impairing their biological functions. Identical cell responses are triggered by manipulation of food, for example, heating/grilling and particularly homogenization, representing cell injury. Cholesterol as well as diets rich in saturated fat have been postulated to accelerate the risk of atherosclerosis while food rich in unsaturated fatty acids has been claimed to lower this risk. However, the fact is that $LOO^{.}$ radicals generated from PUFAs can oxidize cholesterol to toxic cholesterol oxides, simulating a reduction in cholesterol level. In this review it is shown how active $LOO^{.}$ radicals interact with biomolecules at a speed transcending usual molecule–molecule reactions by several orders of magnitude. Here, it is explained how functional groups are fundamentally transformed by an attack of $LOO^{.}$ with an obliteration of essential biomolecules leading to pathological conditions. A serious reconsideration of the health and diet guidelines is required.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	46
Volume Number	20
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2014-11-10
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Atherosclerosis Metabolism Cholesterol Fatty Acids Free Radicals Peroxides Animals Enzymology Etiology Pathology Lipid Peroxidation Research Support, Non-U.S. Gov't Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in