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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Golik, Pawel Borowski, Lukasz S. Stepien, Piotr P. Szczesny, Roman J. Malecki, Michal Wojcik, Magdalena A. |
| Description | Author Affiliation: Szczesny RJ ( Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland. rszczesny@ibb.waw.pl) |
| Abstract | Expression of mitochondrially encoded genes must be finely tuned according to the cell's requirements. Since yeast and human mitochondria have limited possibilities to regulate gene expression by altering the transcription initiation rate, posttranscriptional processes, including RNA degradation, are of great importance. In both organisms mitochondrial RNA degradation seems to be mostly depending on the RNA helicase Suv3. Yeast Suv3 functions in cooperation with Dss1 ribonuclease by forming a two-subunit complex called the mitochondrial degradosome. The human ortholog of Suv3 (hSuv3, hSuv3p, SUPV3L1) is also indispensable for mitochondrial RNA decay but its ribonucleolytic partner has so far escaped identification. In this review we summarize the current knowledge about RNA degradation in human and yeast mitochondria. This article is part of a Special Issue entitled: Mitochondrial Gene Expression. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 9-10 |
| Volume Number | 1819 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation Mitochondria RNA Stability Genetics RNA Adenosine Triphosphate Metabolism DEAD-box RNA Helicases Exoribonucleases Saccharomyces Cerevisiae Saccharomyces Cerevisiae Proteins Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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