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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Blumberg, Amit Bar-yaacov, Dan Mishmar, Dan |
| Description | Author Affiliation: Bar-Yaacov D ( Department of Life Sciences, Ben-Gurion Unniversity of the Negev, Beer Sheva 84105, Israel.) |
| Abstract | Factors required for mitochondrial function are encoded both by the nuclear and mitochondrial genomes. The order of magnitude higher mutation rate of animal mitochondrial DNA (mtDNA) enforces tight co-evolution of mtDNA and nuclear DNA encoded factors. In this essay we argue that such co evolution exists at the population and inter-specific levels and affect disease susceptibility. We also argue for the existence of three modes of co-evolution in the mitochondrial genetic system, which include the interaction of mtDNA and nuclear DNA encoded proteins, nuclear protein – mtDNA-encoded RNA interaction within the mitochondrial translation machinery and nuclear DNA encoded proteins-mtDNA binging sites interaction in the frame of the mtDNA replication and transcription machineries. These modes of co evolution require co-regulation of the interacting factors encoded by the two genomes. Thus co evolution plays an important role in modulating mitochondrial activity. This article is part of a Special Issue entitled: Mitochondrial Gene Expression. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 9-10 |
| Volume Number | 1819 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Biological Evolution DNA, Mitochondrial Genetics Mitochondria Nuclear Proteins DNA Replication Metabolism DNA-Binding Proteins Eukaryota Oxidative Phosphorylation RNA, Messenger RNA-Binding Proteins Transcription, Genetic Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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