NDLI: Rice APOPTOSIS INHIBITOR5 coupled with two DEAD-box adenosine 5'-triphosphate-dependent RNA helicases regulates tapetum degeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Xingwang Gao, Xinqiang Wei, Yi Deng, Li Ouyang, Yidan Chen, Guoxing Li, Xianghua Zhang, Qifa Wu, Changyin
Description	Country affiliation: China Author Affiliation: Li X ( National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan 430070, China.)
Abstract	Programmed cell death (PCD) during tapetum degeneration in postmeiotic anthers is critical for the proper development of male gametophytes in flowering plants. Although several genes involved in this process have been identified recently, the molecular mechanism is still poorly understood. Here, we show that knockout of rice (Oryza sativa) APOPTOSIS INHIBITOR5 (API5), which encodes a putative homolog of antiapoptosis protein Api5 in animals, results in delayed degeneration of the tapetum due to inhibition of the tapetal PCD process leading to defects in formation of male gametophytes. Os API5 is a nuclear protein that interacts with two DEAD-box ATP-dependent RNA helicases, API5-INTERACTING PROTEIN1 (AIP1) and AIP2. AIP1 and AIP2 are homologs of yeast (Saccharomyces cerevisiae) Suppressor of Bad Response to Refrigeration1 protein 2 (SUB2p) that have critical roles in transcription elongation and pre-mRNA splicing. Os AIP1 and AIP2 can form dimers and interact directly with the promoter region of CP1, a rice cysteine protease gene. Suppression of Os AIP1/2 leads to down-regulation of CP1, resulting in sterility, which is highly similar to the effects of suppressed expression of Os CP1. Our results uncover a previously unknown pathway for regulating PCD during tapetum degeneration in rice, one that may be conserved among eukaryotic organisms.
File Format	HTM / HTML
ISSN	10404651
e-ISSN	1531298X
DOI	10.1105/tpc.110.082636
Journal	THE PLANT CELL ONLINE
Issue Number	4
Volume Number	23
Language	English
Publisher	American Society of Plant Biologists
Publisher Date	2011-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Botany Adenosine Triphosphate Metabolism Dead-box Rna Helicases Oryza Sativa Enzymology Plant Proteins Amino Acid Sequence Apoptosis Conserved Sequence Genetics Dna Fragmentation Cytology Ultrastructure Gene Expression Profiling Gene Expression Regulation, Plant Gene Knockdown Techniques Genetic Complementation Test Molecular Sequence Data Mutation Phylogeny Plant Infertility Chemistry Protein Binding Protein Transport Saccharomyces Cerevisiae Subcellular Fractions Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Plant Science

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Rice APOPTOSIS INHIBITOR5 Coupled with Two DEAD-Box Adenosine 5′-Triphosphate-Dependent RNA Helicases Regulates Tapetum Degeneration [W] [OA]

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Rice APOPTOSIS INHIBITOR5 coupled with two DEAD-box adenosine 5'-triphosphate-dependent RNA helicases regulates tapetum degeneration.