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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ishikawa, Makoto Okamura, Hirohiko Ochiai, Kazuhiko Takamura, Haruna Yoshida, Kaya Fujiwara, Natsumi Ozaki, Kazumi |
| Description | Author Affiliation: Ishikawa M ( Department of Oral Healthcare Promotion, The University of Tokushima Graduate School, Kuramoto, Tokushima 770-8504, Japan.) |
| Abstract | Periodontal diseases are common chronic inflammatory disorders that result in the destruction of tissues around teeth. Many clinical studies suggest that periodontal diseases are risk factors for insulin resistance and diabetic mellitus development. However, the molecular mechanisms by which periodontal diseases regulate the progress of diabetes mellitus remain unknown. In this study, we investigated whether Porphyromonas gingivalis ( P.g. ), a major pathogen of periodontal diseases, present in the oral cavity, moves to the liver and affects hepatic glycogen synthesis. SNAP26b-tagged P.g. (SNAP- P.g. ) was introduced into the oral cavity to induce periodontal disease in 4-week old female Balb/c mice. SNAP- P.g. was detected in the liver extracted from SNAP- P.g. -treated mice using nested PCR analysis. High blood glucose levels tended to promote SNAP- P.g. translocation from the oral cavity to the liver in mice. Periodic acid-Schiff staining suggested that hepatic glycogen synthesis decreased in SNAP- P.g. -treated mice. SNAP- P.g. was also internalized into the human hepatoma cell line HepG2, and this attenuated the phosphorylation of insulin receptor substrate (IRS)-1, Akt and glycogen synthase kinase-3β induced by insulin. Insulin-induced glycogen synthesis was suppressed by SNAP- P.g. in HepG2 cells. Our results suggest that P.g. translocation from the oral cavity to the liver may contribute to the progress of diabetes mellitus by influencing hepatic glycogenesis. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 12 |
| Volume Number | 1832 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Bacteroidaceae Infections Complications Gingiva Microbiology Glycogen Synthase Kinase 3 Metabolism Liver Glycogen Liver Periodontitis Etiology Porphyromonas Gingivalis Pathogenicity Proto-Oncogene Proteins C-akt Animals Pathology Blotting, Western Genetics Hep G2 Cells Insulin Receptor Substrate Proteins Mice Mice, Inbred BALB C Mouth Mucosa Phosphorylation RNA, Messenger Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction SNARE Proteins Signal Transduction Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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