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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Morgan, Mary E. Garssen, Johan Zheng, Bin Kraneveld, Aletta D. Van De Kant, Hendrik J. G. Folkerts, Gert |
| Description | Author Affiliation: Zheng B ( Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands.) |
| Abstract | Pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), contribute to the development of intestinal inflammatory diseases, like inflammatory bowel disease (IBD). Supporting investigations of the underlying mechanisms of IBD, this study provides an extensive PRR expression survey together with T-cell associated factors along the murine colon during experimental colitis. 8–12 week-old C57BL/6 mice were treated with dextran sodium sulfate (DSS) to induce colitis. The mRNA expression levels of Tlr1 – 9 , Nod1 , Nod2 , T cell subset-associated master transcription factors and cytokines were determined using qPCR. The expression of TLR2, 4, 5 and 6 was determined with immunohistochemistry. Th1 and Th17 associated responses were quantified in the mesenteric lymph nodes (mLNs) using flow cytometry. In DSS treated mice, the mRNA expression of the majority of PRRs was increased relative to healthy controls and correlated with the degree of inflammation. The exceptions were Tlr1 and Tlr5 , which displayed unchanged and down-regulated transcription, respectively. Furthermore, in healthy animals, there was increased transcription of Tlr2 , 3 and 5 near the caecum as opposed the region near the rectum. Within the inflamed regions, the mRNA expression of Th1-, Th17- and regulatory T-cell associated cytokines was enhanced, while there was no change for Th2-associated cytokines. In agreement with the mRNA expression, enhanced IFNγ and IL-17 producing cells were observed in stimulated mLNs. This study provides an extensive expression survey of PRRs along the colon during the acute colitis and shows that the induced inflammation is characterized by a Th1- and IL-17 mediated cytokine response. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 12 |
| Volume Number | 1832 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Colitis Pathology Gene Expression Regulation Nod1 Signaling Adaptor Protein Genetics Nod2 Signaling Adaptor Protein Receptors, Pattern Recognition T-Lymphocytes, Regulatory Immunology Toll-Like Receptors Transcription, Genetic Acute Disease Animals Blotting, Western Chemically Induced Cytokines Metabolism Dextran Sulfate Toxicity Flow Cytometry Immunoenzyme Techniques Inflammation Etiology Interleukin-17 Mice Mice, Inbred C57BL RNA, Messenger Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction T-Lymphocyte Subsets Th1 Cells Th17 Cells Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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