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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shevchuk, Igor Varikmaa, Minna Chekulayev, Vladimir Tepp, Kersti Bagur, Rafaela Grichine, Alexei Kaambre, Tuuli Metsis, Madis Guzun, Rita Timohhina, Natalja Kuznetsov, Andrey V. Boucher, François Saks, Valdur |
| Description | Author Affiliation: Varikmaa M ( INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France); Bagur R ( INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France); Kaambre T ( Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.); Grichine A ( Life Science Imaging - In Vitro Platform, IAB CRI U823 Inserm, Joseph Fourier University, Grenoble, France.); Timohhina N ( Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.); Tepp K ( Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.); Shevchuk I ( Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.); Chekulayev V ( Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.); Metsis M ( Tallinn University of Technology, Faculty of Science, Centre for Biology of Integrated Systems, Estonia.); Boucher F ( Experimental, Theoretical and Applied Cardio-Respiratory Physiology, Laboratory TIMC-IMAG, Joseph Fourier University, Grenoble, France.); Saks V ( INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France); Kuznetsov AV ( Cardiac Surgery Laboratory, Department of Heart Surgery, Innsbruck Medical University, Innsbruck A-6020, Austria.); Guzun R ( INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France) |
| Abstract | The aim of this work was to study the regulation of respiration and energy fluxes in permeabilized oxidative and glycolytic skeletal muscle fibers, focusing also on the role of cytoskeletal protein tubulin βII isotype in mitochondrial metabolism and organization. By analyzing accessibility of mitochondrial ADP, using respirometry and pyruvate kinase–phosphoenolpyruvate trapping system for ADP, we show that the apparent affinity of respiration for ADP can be directly linked to the permeability of the mitochondrial outer membrane (MOM). Previous studies have shown that MOM permeability in cardiomyocytes can be regulated by VDAC interaction with cytoskeletal protein, βII tubulin. We found that in oxidative soleus skeletal muscle the high apparent K $_{m}$ for ADP is associated with low MOM permeability and high expression of non-polymerized βII tubulin. Very low expression of non-polymerized form of βII tubulin in glycolytic muscles is associated with high MOM permeability for adenine nucleotides (low apparent K $_{m}$ for ADP). |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 2 |
| Volume Number | 1837 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cytoskeleton Metabolism Mitochondria Muscle, Striated Adenosine Diphosphate Animals Blotting, Western Cell Respiration Cytoskeletal Proteins Energy Metabolism Metabolic Flux Analysis Microscopy, Confocal Mitochondrial Membranes Myocardium Permeability Rats, Wistar Tubulin Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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