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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nisr, Raid B. Affourtit, Charles |
| Description | Author Affiliation: Nisr RB ( School of Biomedical & Healthcare Sciences, Plymouth University, Drake Circus, Plymouth, UK. Electronic address: raid.nisr@plymouth.ac.uk.); Affourtit C ( School of Biomedical & Healthcare Sciences, Plymouth University, Drake Circus, Plymouth, UK. Electronic address: charles.affourtit@plymouth.ac.uk.) |
| Abstract | Insulin is essential for the regulation of fuel metabolism and triggers the uptake of glucose by skeletal muscle. The imported glucose is either stored or broken down, as insulin stimulates glycogenesis and ATP synthesis. The mechanism by which ATP production is increased is incompletely understood at present and, generally, relatively little functional information is available on the effect of insulin on mitochondrial function. In this paper we have exploited extracellular flux technology to investigate insulin effects on the bioenergetics of rat (L6) and human skeletal muscle myoblasts and myotubes. We demonstrate that a 20-min insulin exposure significantly increases (i) the cell respiratory control ratio, (ii) the coupling efficiency of oxidative phosphorylation, and (iii) the glucose sensitivity of anaerobic glycolysis. The improvement of mitochondrial function is explained by an insulin-induced immediate decrease of mitochondrial proton leak. Palmitate exposure annuls the beneficial mitochondrial effects of insulin. Our data improve the mechanistic understanding of insulin-stimulated ATP synthesis, and reveal a hitherto undisclosed insulin sensitivity of cellular bioenergetics that suggests a novel way of detecting insulin responsiveness of cells. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 2 |
| Volume Number | 1837 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Insulin Pharmacology Mitochondria Metabolism Muscle, Skeletal Oxidative Phosphorylation Drug Effects Anaerobiosis Animals Cell Line Cell Respiration Glucose Glycolysis Oxygen Consumption Palmitic Acid Protons Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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