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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Salas, Alvaro Cornejo, Rodrigo Goñi, Daniela Venegas, Pablo Romero, Carlos |
| Description | Author Affiliation: Cornejo R ( Medicine Department, Critical Care Unit, Clinical Hospital Universidad de Chile, Santiago, Región Metropolitana, Chile. racornej@gmail.com) |
| Abstract | The authors describe the case of a 61-year-old woman who was admitted to our intensive care unit (ICU) due to impaired consciousness associated with generalised seizures. Her cerebrospinal fluid, electrolytes, acid-base analysis, and common laboratory and toxicology tests were normal. An MRI ruled out the presence of stroke or haemorrhage but showed severe leukoencephalopathy. Parkinson's disease, Creuzfeld-Jacob disease, vascular alterations, cancer, and rheumatological and metabolic diseases were evaluated and excluded. In view of her history of hypothyroidism despite adequate hormonal replacement and clinical behaviour, Hashimoto's encephalopathy was considered. Anti-thyroperoxidase levels were above 3000 IU/ml. The patient received 5 g of methylprednisolone followed by prednisone, but after a favourable initial response, returned to a comatose state. However, after administration of intravenous immunoglobulin (IVIG) 2 g/kg, the patient recovered with resolution of neurological symptoms and was discharged from the ICU 4 days after finishing IVIG treatment. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2010 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Brain Diseases Drug Therapy Hashimoto Disease Immunoglobulins, Intravenous Therapeutic Use Encephalitis Remission Induction Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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