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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sisodiya, Sanjay M. Sander, Josemir W. Kensche, Maria |
| Description | Author Affiliation: Kensche M ( Institute of Neurology, University College London, London, UK. maria.kensche@charite.de) |
| Abstract | Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus. It is available in various forms, including a buccal preparation with a strength of 10 mg/1 ml. Midazolam is a licensed medication, but the buccal formulation is currently used off-licence. The prescriber takes ultimate responsibility for its use in this way. Administered by a trained person, it is receiving widespread acceptance as an alternative and effective treatment to rectally-administered diazepam in the community. The commonest side effects of midazolam are drowsiness and somnolence, although respiratory depression and paradoxical reactions, for example, agitation, restlessness and disorientation, may also occur. Hypotension is said to be a rare side effect, but with no reported cases in people administered buccal midazolam. The authors report a case of significant hypotension associated with administration of buccal midazolam for seizure management. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2010 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | GABA Modulators Adverse Effects Hypotension Chemically Induced Midazolam Administration, Buccal Epilepsy Drug Therapy Administration & Dosage Severity Of Illness Index Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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