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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Coakley, Gerald Cosgrove, Catherine Lockwood, Diana Khan, Anjum |
| Description | Author Affiliation: Khan A ( Department of Haematology, Guy's and St Thomas' Hospital NHS Trust, London, UK. medikhan@yahoo.com) |
| Abstract | A 74-year-old woman with a history of psoriatic arthritis was referred to the Hospital for Tropical Diseases following investigation of a skin lesion that had failed to heal after a visit to Malta 2 years previously. Skin biopsy had revealed invasion of Leishmania amastigotes. She reported a recent history of weight loss, dry cough and dyspnoea, and was investigated for pancytopenia and hepatosplenomegaly. Bone marrow biopsy confirmed the diagnosis of visceral leishmaniasis and she responded well to treatment with intravenous liposomal amphotericin B. Recent rheumatological treatment with adalimumab, a monoclonal antibody to tumour necrosis factor , was thought to be the factor responsible for causing the cutaneous lesion to become disseminated. This case highlights an unexpected adverse effect of novel immunosuppressants. As the use of biologics becomes widespread, there is an increasing need for clinical surveillance. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2010 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Antibodies, Monoclonal, Humanized Adverse Effects Antirheumatic Agents Arthritis, Psoriatic Drug Therapy Leishmaniasis, Visceral Chemically Induced Opportunistic Infections Tumor Necrosis Factor-alpha Antagonists & Inhibitors Adalimumab Therapeutic Use Biopsy Bone Marrow Pathology Diagnosis Skin Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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