NDLI: A mutant of Escherichia coli defective in leucyl, phenylalanyl-tRNA-protein transferase.

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A mutant of Escherichia coli defective in leucyl, phenylalanyl-tRNA-protein transferase.

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A mutant of Escherichia coli defective in leucyl, phenylalanyl-tRNA-protein transferase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Soffer, R. L. Savage, M.
Abstract	A mutant of E. coli that lacks leucyl,-phenylalanyl-tRNA-protein transferase (EC 2.3.2.6) has been isolated. Ability to produce the two activities could be introduced into the mutant from an F' strain whose episome contains genetic material located between 45 and 54 min on the E. coli chromosome. When grown into stationary phase and resuspended in minimal medium with glycerol, the mutant exhibited a marked lag before resuming growth. Revertants that did not show this lag were selected and were found to have regained both transfer activities. Extracts of wild-type, mutant, and revertant strains were compared as acceptors for the enzymatic transfer of radioactive phenylalanine. Analysis of the labeled polypeptides by disc gel electrophoresis indicated that certain potential acceptors may be preferentially acylated in vivo. These data provide genetic confirmation that the same enzyme protein catalyzes the transfer of leucine and phenylalanine and suggest that leucyl,phenylalanyl-tRNA-protein transferase is involved in a growth regulatory mechanism.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	71
Language	English
Publisher	National Academy of Sciences
Publisher Date	1974-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Acyltransferases Biosynthesis Escherichia Coli Enzymology Genes Mutation Metabolism Autoradiography Bacterial Proteins Carbon Radioisotopes Electrophoresis, Disc Growth & Development Leucine Molecular Weight Phenylalanine RNA, Transfer Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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