NDLI: Evidence for allosterism in in vitro DNA synthesis on RNA templates.

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Evidence for allosterism in in vitro DNA synthesis on RNA templates.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Modak, M. J. Marcus, S. L. Cavalieri, L. F.
Abstract	Hemoglobin mRNA and (rA)(n).(dT)(10) have been used as primer-templates in a kinetic study of DNA synthesis with Escherichia coli DNA polymerase I (DNA nucleotidyl transferase, EC 2.7.7.7) and Mason-Pfizer monkey virus reverse transcriptase (RNA-directed DNA polymerase). The rate versus enzyme concentration curve is sigmoidal and is consistent with a cooperative phenomenon. The results could be interpreted in terms of the formation of an active complex containing enzyme dimers (or oligomers) on the primer-template. We have also observed sigmoidal kinetics in rate versus deoxynucleotide triphosphate concentration. These results are consistent with an allosteric mechanism in which the triphosphates act as both modifiers and DNA precursors. In the critical range, a 6- to 8-fold increase in both enzyme and triphosphate concentrations can lead to a 1500-fold increase in the rate of synthesis on an RNA template. Thus, small changes in enzyme and precursor concentrations could play a regulatory role in vivo.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	71
Language	English
Publisher	National Academy of Sciences
Publisher Date	1974-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Nucleotidyltransferases Metabolism DNA Biosynthesis RNA-Directed DNA Polymerase Adenosine Triphosphate Allosteric Regulation Animals Binding Sites Cytosine Nucleotides Escherichia Coli Enzymology Guanosine Triphosphate Haplorhini Hemoglobins Kinetics Oncogenic Viruses Polynucleotides RNA Viruses RNA, Messenger Templates, Genetic Thymine Nucleotides Tritium Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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