NDLI: The explanation for the blockade of glycolysis in early mouse embryos.

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The explanation for the blockade of glycolysis in early mouse embryos.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barbehenn, E. K. Wales, R. G. Lowry, O. H.
Abstract	The reason for the failure of early-stage mouse embryos to grow on glucose alone was investigated by measurement of glucose-6-phosphate, fructose-1,6-bisphosphate plus triose phosphates, citrate, and malate in individual embryos during starvation and refeeding with glucose or glucose plus pyruvate. The results indicate a block at the 6-phosphofructokinase (EC 2.7.1.11) step at early stages, which is later removed. Although there seems to be no early difficulty in phosphorylation of glucose, maximum glucose-6-phosphate levels (and probably fructose-6-phosphate levels) are much lower at early stages than at later stages. The increase in fructose-6-phosphate with age may be the major cause of the increase in 6-phosphofructokinase activity. Unusually high citrate levels at all ages may help to keep this enzyme strongly inhibited until the increase in fructose-6-phosphate occurs. The changes in metabolite levels also indicate an early defect in mobilization of glycogen and a probably less important defect in the citrate cycle.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	71
Language	English
Publisher	National Academy of Sciences
Publisher Date	1974-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Embryo, Mammalian Metabolism Glycolysis Animals Citrates Culture Media Culture Techniques Enzymology Fructosephosphates Glucosephosphates Hexokinase Malates Mice Phosphofructokinase-1 Phosphorylases Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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