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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Machida, Y. Samuelsson, B. Corey, E. J. Malmsten, C. L. Nicolaou, K. C. |
| Abstract | The 9,11-azo-prostanoid III [(5Z, 9alpha, 11alpha, 13E, 15S)-9, 11-azo-15-hydroxyprosta-5,13-dienoic acid] has been obtained by synthesis and tested for biological activity in systems which are responsive to the prostaglandin endoperoxides PGH2 (I) and PGG2 (II). The azo analog III is a powerful mimic of these endoperoxides with reference to platelet aggregation and release of serotonin when added to human platelet-rich plasma. The analog III is substantially more active (about 7 fold) than PGG2 in stimulating muscle contraction in the isolated rabbit aorta strip. The very great stability of III relative to PGH2 and PGG2 and its potency as a mimic of these important substances suggest that this azo analog will be of considerable value in future studies of the prostaglandin endoperoxides. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 9 |
| Volume Number | 72 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1975-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Azo Compounds Pharmacology Prostaglandins Aorta Drug Effects Chemical Synthesis Dose-Response Relationship, Drug Muscle Contraction Peroxides Platelet Adhesiveness Serotonin Metabolism Stimulation, Chemical Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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