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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Satrustegui, J. Cori, C. F. Garland, R. C. Gluecksohn-waelsch, S. |
| Abstract | Plasma protein synthesis was studied in mice bearing x-ray induced lethal mutations at the albino locus. Newborn albino mutants showed a decrease in each of the three principal plasma proteins, albumin, alpha-fetoprotein, and transferrin, when compared with colored littermate controls. Incorporation of [14C]leucine into plasma proteins of the newborn albinos 30 min after injection was only 1/5 that of the controls, but incorporation into total liver protein was only slightly diminished. Incorporation of [14C]leucine into an albumin fraction obtained by immunoprecipitation from livers incubated in vitro in an amino acid mixture was also strongly diminished. Thus, the liver of 18-day-old albino fetuses incorporated into this fraction 1/3 and that of newborn albinos 1/8 as much as the controls, but in both cases the incorporation into total liver protein was only 25% less than in the respective controls. These results indicate that the rather severe structural abnormalities observed in the mutants in the endoplasmic reticulum and the Golgi apparatus are not associated with a general deficiency of hepatic protein synthesis. Instead the data from this and previous work show that the progressive deficiency from fetal life to birth involves certain specific proteins represented by several perinatally developing enzymes and by plasma proteins. It is suggested that the mutational effects observed in these mice are due to deletions involving regulatory rather than structural genes at or near the albino locus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 10 |
| Volume Number | 73 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1976-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Albinism Genetics Blood Proteins Biosynthesis Liver Metabolism Mutation Alleles Animals Animals, Newborn Endoplasmic Reticulum Fetus Genes, Regulator Radiation Effects Genetic Linkage Golgi Apparatus Ultrastructure Mice Serum Albumin Transferrin X-Rays Alpha-Fetoproteins Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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