NDLI: A structural model of radiation effects in living cells.

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Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action.

Erythrocyte membranes undergo cooperative, pH-sensitive state transitions in the physiological temperature range: evidence from Raman spectroscopy.

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Identification of nonhistone chromatin proteins in chromatin subunits.

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Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme.

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Kinetic evidence for hapten-induced conformational transition in immunoglobin MOPC 460.

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Cellular cholesterol ester accumulation induced by free cholesterol-rich lipid dispersions.

Nucleotide sequences in mouse DNA and RNA specific for Moloney sarcoma virus.

C-type virus particle formation in erythroblastic islands in spleens of C3Hf mice injected with erythropoietin.

Replication of murine leukemia virus in bone marrow-derived lymphocytes.

Opiate receptor: autoradiographic localization in rat brain.

Deficiency in plasma protein synthesis caused by x-ray-incuded lethal albino alleles in mouse.

Anticomplementary nature of smaller DNA produced during synthesis of extensive DNA copies of poliovirus RNA.

Stepwise biosynthesis in vitro of globin genes from globin mRNA by DNA polymerase of avian myeloblastosis virus.

Human somatotropin: biological characterization of the recombinant molecule.

A new class of genetically transmitted retravirus isolated from Mus cervicolor.

Characterization of heteropolymeric hexosaminidase A in human X mouse hybrid cells.

Molecular determinants of immunogenicity: the immunon model of immune response.

Insulin release and phosphate ion efflux from rat pancreatic islets induced by L-leucine and its nonmetabolizable analogue, 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid.

Conversion of beta-galactosidase to a membrane-bound state by gene fusion.

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Amplification in Escherichia coli of enzymes involved in genetic recombination: construction of hybrid ColE1 plasmids carrying the structural gene for exonuclease I.

Regulation of ornithine decarboxylase activity by guanine nucleotides: in vivo test in potassium-depleted Escherichia coli.

Mechanism of DNA elongation catalyzed by Escherichia coli DNA polymerase III, dnaZ protein, and DNA elongation factors I and III.

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Members and organization of The National Academy of Sciences.

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

Aryl 4-monooxygenase and cytochrome P-450 in the aorta: possible role in atherosclerosis.

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A structural model of radiation effects in living cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Neyman, J. Puri, P. S.
Abstract	The chance mechanism of cell damage and of repair in the course of irradiation involves two details familiar to biologists that thus far seem to have been overlooked in mathematical treatment. One of these details is that, generally, the passage of a single 'primary' radiation particle generates a 'cluster' of secondaries which can produce 'hits' that damage the living cell. With high linear energy transfer, each cluster contains very many secondary particles. With low linear energy transfer, the number of secondaries per cluster is generally small. The second overlooked detail of the chance mechanism is concerned with what may be called the time scales of radiation damage and of the subsequent repair. The generation of a cluster of secondary particles and the possible hits occur so rapidly that, for all practical purposes, they may be considered as occurring instantly. On the other hand, the subsequent changes in the damaged cells appear to require measurable amounts of time. The constructed stochastic model embodies these details, the clustering of secondary particles and the time scale difference. The results explain certain details of observed phenomena.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	73
Language	English
Publisher	National Academy of Sciences
Publisher Date	1976-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Models, Biological Radiation Effects Animals Cells Dose-Response Relationship, Radiation Energy Transfer Gamma Rays Mice Neoplasms, Radiation-Induced Neutrons X-Rays Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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