NDLI: Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus.

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Siderophore electrochemistry: relation to intracellular iron release mechanism.

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Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus.

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High-resolution 13C nuclear magnetic resonance studies of glucose metabolism in Escherichia coli.

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Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bluestein, H. G.
Abstract	Sera from patients with systemic lupus erythematosus (SLE) have been tested for antibody to a human neuronal cell line, SK-N-SH, derived from a metastatic neuroblastoma. With a complement-dependent (51)Cr-release cytotoxicity assay, 75% of SLE sera had antineuronal activity mediated by IgM antibody. Most of the sera containing this IgM neurocytotoxic antibody were also cytotoxic to the human glial cell lines A-172 and U-118MG. The sera did not mediate complement-dependent (51)Cr release when tested against normal human fibroblasts or peripheral blood lymphocytes. IgG antineuronal antibody was detected in 17% of SLE sera by an antibody-dependent, cell-mediated cytotoxicity assay with SK-N-SH cells as targets. The relationship of IgM and IgG antineuronal antibodies to the antilymphocyte antibodies present in SLE sera was evaluated by a series of crossabsorption experiments using SK-N-SH cells to remove neuronal antibodies and WI-L2 (human lymphoblasts) to remove antilymphocyte antibodies. Most of the complement-dependent neurocytotoxicity was not removed by multiple lymphoblast absorptions, although the WI-L2 cells readily removed lymphocytotoxic activity as assayed on normal lymphocytes. Absorption with SK-N-SH cells removed most, but not all, of the lymphocytotoxic antibody. Thus, although lymphocytotoxic antibodies reactive with membrane antigens shared by lymphocytes and brain may constitute a subset of the antibodies to neural cells, most of the antineuronal activity in SLE serum is directed at other cell surface antigens expressed on neuronal and glial cells. Should they gain access to the brain, these antibodies have the potential to produce neuropathology, but their presence in the nervous system of patients with the neuropsychiatric manifestations of SLE is yet to be documented.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	75
Language	English
Publisher	National Academy of Sciences
Publisher Date	1978-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies Lupus Erythematosus, Systemic Immunology Neurons Cell Line Complement System Proteins Cytotoxicity Tests, Immunologic Immunoglobulin G Immunoglobulin M Lymphocytes Neuroglia Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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