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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schiller, R. M. Isselbacher, K. J. Nishino, H. Tillotson, L. G. Inui, K. I. |
| Abstract | Plasma membrane fractions isolated from mouse fibroblast BALB/c 3T3 cells transformed by simian virus 40 were partially purified by treatment with dimethylmaleic anhydride followed by extraction with 2% cholate. The extracted proteins were combined with exogenous phospholipids and eluted through a Sephadex G50 column. Reconstituted vesicles thus obtained were shown to possess the ability of Na+-stimulated transport of alpha-aminoisobutyric acid. The simultaneous addition of NaSCN and alpha-aminoisobutyric acid to these vesicles produced a transient accumulation above the equilibrium level (overshoot, active transport). The Na+-stimulated transport of alpha-aminoisobutyric acid was sensitive to the accompanying anion and to the temperature of incubation. The results demonstrate that partially purified membrane proteins of mouse fibroblast cells can be incorporated into the liposomes that have the characteristics of Na+-stimulated and electrochemically sensitive active transport of alpha-aminoisobutyric acid. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 75 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1978-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Aminoisobutyric Acids Metabolism Cell Membrane Membranes, Artificial Sodium Pharmacology Biological Transport, Active Cell Transformation, Viral Cells, Cultured Chlorides Liposomes Maleic Anhydrides Membrane Proteins Isolation & Purification Simian Virus 40 Temperature Thiocyanates Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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