NDLI: Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

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Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

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Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shinefeld, L. Siden, E. Alt, F. W. Sato, V. Baltimore, D.
Abstract	Immunoglobulin (Ig) gene expression has been followed during the later stages of development of the murine fetal liver. Biosynthetic labeling and immunoprecipitation were used to isolate Ig-related polypeptides from fetal and neonatal livers. By examination of the specific immune precipitates, the earliest detectable Ig was shown to consist only of mu heavy chain. At about the time of birth, when light chain synthesis became evident, separation of surface Ig-positive cells from surface Ig-negative cells by using anti-Ig-coated dishes showed that cells lacking surface Ig (pre-B lymphocytes) synthesized only mu chains. Thus, commencement of light chain synthesis was closely coordinated with the appearance of surface Ig. Ig RNA species were examined by electrophoretic fractionation and hybridization with cloned Ig DNA sequences. The sizes and amounts of Ig mRNA were found to correlate with the pattern of mu and light chain protein biosynthesis. mu chain RNA species appeared earlier in gestation than light chain RNA did, and only after birth did light chain sequences reach levels equivalent to those of mu chain. Cell populations enriched in pre-B lymphocytes also contained an excess of mu over light chain mRNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	78
Language	English
Publisher	National Academy of Sciences
Publisher Date	1981-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology Immunoglobulin Heavy Chains Genetics Immunoglobulin Light Chains Immunoglobulin Mu-Chains Protein Biosynthesis Transcription, Genetic Animals Fetus Gestational Age Liver Mice Mice, Inbred BALB C Poly A Pregnancy RNA, Messenger Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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