NDLI: Phospholipid methylation and phospholipase A2 activation in cytotoxicity by human natural killer cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1981 Volume: 78 Issue: 12

Year: 1981 Volume: 78 Issue: 11

Year: 1981 Volume: 78 Issue: 10

Year: 1981 Volume: 78 Issue: 9

Year: 1981 Volume: 78 Issue: 8

Year: 1981 Volume: 78 Issue: 7

Year: 1981 Volume: 78 Issue: 6

A cloned cyanobacterial gene for glutamine synthetase functions in Escherichia coli, but the enzyme is not adenylylated.

Spurious conformational transitions in proteins?

Antihistaminics, local anesthetics, and other amines as antiviral agents.

Microsomal acetyl-CoA carboxylase: evidence for association of enzyme polymer with liver microsomes.

Physical and genetic characterization of the glnA--glnG region of the Escherichia coli chromosome.

Somatostatin receptors: identification and characterization in rat brain membranes.

Establishment of the interferon-mediated antiviral state: possible role of superoxide dismutase.

Asialoglycoprotein receptor mediates the toxic effects of an asialofetuin-diphtheria toxin fragment A conjugate on cultured rat hepatocytes.

Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles.

Partial characterization of gamma (immune) interferon mRNA extracted from human lymphocytes.

Cloning and sequence of several alpha 2u-globulin cDNAs.

Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.

Differentiation of fetal liver cells in vitro.

Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype.

Prediction of protein antigenic determinants from amino acid sequences.

Human T cell surface antigens bearing a structural relationship to HLA antigens.

Extraction and immunochemical characterization of cholecystokinin-like peptides from pig and rat brain.

Acetylcholine-induced cation translocation across cell membranes and inactivation of the acetylcholine receptor: chemical kinetic measurements in the millisecond time region.

Complete nucleotide sequence of minicircle kinetoplast DNA from Trypanosoma equiperdum.

Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.

Hydrogen bonding, overlap geometry, and sequence specificity in anthracycline antitumor antibiotic.DNA complexes in solution.

Identification and quantification of the rat hepatocyte asialoglycoprotein receptor.

Translational control in lysates of Drosophila melanogaster cells.

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

Molecular cloning and comparative analyses of the genomes of simian sarcoma virus and its associated helper virus.

On the mechanism of retrovirus-induced avian lymphoid leukosis: deletion and integration of the proviruses.

Resolution of cointegrates between transposons gamma delta and Tn3 defines the recombination site.

Isolation of a molybdenum--iron cluster from nitrogenase.

ATP-driven active transport in right-side-out bacterial membrane vesicles.

Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing.

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

Degradative inactivation of cyclic AMP-dependent protein kinase by a membranal proteinase is restricted to the free catalytic subunit in its native conformation.

Stable chromosomal integration of the entire nitrogen fixation gene cluster from Klebsiella pneumoniae in yeast.

Cloning a cDNA for the pro-alpha 2 chain of human type I collagen.

Mosaic nonequilibrium thermodynamics describes biological energy transduction.

Agonist-activated ionic channels in acetylcholine receptor reconstituted into planar lipid bilayers.

Differential effects of transforming avian RNA tumor viruses on avian macrophages.

DNA double-strand breaks induced in normal human cells during the repair of ultraviolet light damage.

Ciliary membrane vesicles of paramecium contain the voltage-sensitive calcium channel.

Estimation of genetic variation at the DNA level from restriction endonuclease data.

Identification of the dnaQ gene product and location of the structural gene for RNase H of Escherichia coli by cloning of the genes.

Production of antigen-specific suppressive T cell factor by radiation leukemia virus-transformed suppressor T cells.

Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.

Immunochemical delineation of an oncofetal antigen on normal and simian virus 40-transformed human fetal melanocytes.

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.

Histidine modification with diethyl pyrocarbonate shows heterogeneity of benzodiazepine receptors.

Rapid recovery of function after partial denervation of the rat pineal gland suggests a novel mechanism for neural plasticity.

Cyclic GMP releases calcium from disc membranes of vertebrate photoreceptors.

Characterization of specific receptors for calcitonin in porcine lung.

Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors.

Oscillations and control features in glycolysis: analysis of resonance effects.

Assignment of the human gene for liver-type 6-phosphofructokinase isozyme (PFKL) to chromosome 21 by using somatic cell hybrids and monoclonal anti-L antibody.

Functional deletion of different Ly-1 T-cell-inducer subset activities by Ly-2 suppressor T lymphocytes.

Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens.

Organization of four mouse lambda light chain immunoglobulin genes.

Sequence homologies in the 5' regions of four Drosophila heat-shock genes.

A novel type of T-T cell interaction removes the requirement for I-B region in the H-2 complex.

Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus.

Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.

Cellular, molecular, and genetic characteristics of T cell reactivity to collagen in man.

Conditioning of leg position in normal and mutant Drosophila.

Acridine dyes and other DNA-intercalating agents induce the luminescence system of luminous bacteria and their dark variants.

Hepatic calcium efflux during cytochrome P-450-dependent drug oxidations at the endoplasmic reticulum in intact liver.

Interaction of tubulin with ribose-modified analogs of GTP and GDP: evidence for two mutually exclusive exchangeable nucleotide binding sites.

Control region for adenovirus VA RNA transcription.

Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

Bacteriorhodopsin: partial sequence of mRNA provides amino acid sequence in the precursor region.

Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution.

Modification of microtubule steady-state dynamics by phosphorylation of the microtubule-associated proteins.

Gravitational field enhances permeability of biological membranes to sucrose: an experimental refutation of sucrose-space hypothesis.

Heat shock proteins are methylated in avian and mammalian cells.

Dexamethasone 21-mesylate: an affinity label of glucocorticoid receptors from rat hepatoma tissue culture cells.

Antibodies specific for left-handed Z-DNA.

Fluctuation x-ray scattering from biological particles in frozen solution by using synchrotron radiation.

Electron microscopy shows periodic structure in collagen fibril cross sections.

Anesthetics and high-pressure interaction upon elastic properties of a polymer membrane.

Matrix control of protein diffusion in biological membranes.

Resonance Raman investigation of dioxygen bonding in oxycobaltmyoglobin and oxycobalthemoglobin: structural implication of splittings of the bound O--O stretching vibration.

Glucose induces two amino acid transport systems in Chlorella.

ATP-dependent regulation of cytoplasmic microtubule disassembly.

Emergence of tumorigenic cells during the course of Friend virus leukemias.

Novel role of calcium in exocytosis: mechanism of nematocyst discharge as shown by x-ray microanalysis.

Self-renewal of hemopoietic stem cells during mixed colony formation in vitro.

Mutated beta-actin gene: coexpression with an unmutated allele in a chemically transformed human fibroblast cell line.

Cell-cycle dependence of induced hemoglobin synthesis in Friend erythroleukemia cells temperature-sensitive for growth.

Augmentation of human monocyte opsonin-independent phagocytosis by fragments of human plasma fibronectin.

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.

On the possibility of metabolic control of replicon 'misfiring': relationship to emergence of malignant phenotypes in mammalian cell lineages.

Crystalline arrays of membrane-bound acetylcholine receptor.

In vitro assembly of homopolymer and copolymer filaments from intermediate filament subunits of muscle and fibroblastic cells.

Comparison of poly(A)-mRNA prepared from membranes and free polyribosomes of mouse liver.

Cell multiplication in metazoans: evidence for negative control of initiation in rat fibroblasts.

Alterations in chromatin structure during early sea urchin embryogenesis.

Possible functions of mesenchyme cell-derived fibronectin during formation of basal lamina.

Sulfation of a cell surface glycoprotein correlates with the developmental program during embryogenesis of Volvox carteri.

Genetic diversity of UV-sensitive DNA repair mutants of Chinese hamster ovary cells.

Location of the 18/28S ribosomal RNA genes in two Hawaiian Drosophila species by monoclonal immunological identification of RNA.DNA hybrids in situ.

Localization of a unique gene by direct hybridization in situ.

Genetic divergence between rodent species assessed by using two-dimensional electrophoresis.

Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA.

Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complex.

Phospholipid methylation and phospholipase A2 activation in cytotoxicity by human natural killer cells.

Identification of a population of bipotent stem cells in the HL60 human promyelocytic leukemia cell line.

Gustin concentration changes relative to salivary zinc and taste in humans.

Altered RNA/protein ratio associated with the induction of differentiation of Friend erythroleukemia cells.

Evidence for a lipoprotein carrier in human plasma catalyzing sterol efflux from cultured fibroblasts and its relationship to lecithin:cholesterol acyltransferase.

Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata.

Changes in protein synthesis underlying functional plasticity in immature monkey visual system.

Adipogenic and anti-adipogenic factors in the pituitary and other organs.

Bacillus licheniformis penicillinase: cleavages and attachment of lipid during cotranslational secretion.

Expression of cell surface markers after human B lymphocyte activation.

Retrovirus-encoded transformation-specific polyproteins: expression coordinated with malignant phenotype in cells from different germ layers.

Calcium-binding sites on sensory processes in vertebrate hair cells.

Expression in Escherichia coli of biologically active enzyme by a DNA sequence coding for the human plasminogen activator urokinase.

recA protein of Escherichia coli promotes branch migration, a kinetically distinct phase of DNA strand exchange.

Repair of DNA double-strand breaks in Escherichia coli cells requires synthesis of proteins that can be induced by UV light.

Changes in the promoter range of RNA polymerase resulting from bacteriophage T4-induced modification of core enzyme.

Amino acid sequence of Escherichia coli alkaline phosphatase.

Bacillus licheniformis penicillinase synthesized in Escherichia coli contains covalently linked fatty acid and glyceride.

Lipoprotein nature of Bacillus licheniformis membrane penicillinase.

Direct selection procedure for the isolation of functional centromeric DNA.

Statistical analysis of the Ames Salmonella/microsome test.

Roles of macrophage Fc and C3b receptors in phagocytosis of immunologically coated Cryptococcus neoformans.

Angiotensin II immunoreactivity coexists with renin in the juxtaglomerular granular cells of the kidney.

Role of basal lamina in neoplastic disorganization of tissue architecture.

Year: 1981 Volume: 78 Issue: 5

Year: 1981 Volume: 78 Issue: 4

Year: 1981 Volume: 78 Issue: 3

Year: 1981 Volume: 78 Issue: 2

Year: 1981 Volume: 78 Issue: 1

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Phospholipid methylation and phospholipase A2 activation in cytotoxicity by human natural killer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hirata, F. Herberman, R. B. Axelrod, J. Hoffman, T. Fraser, B. A. Goldfarb, R. H. Bougnoux, P.
Abstract	The role of phospholipid methylation and phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) in natural killer (NK) function by human peripheral blood mononuclear cells was studied. Pretreatment of effector cells with a methyltransferase inhibitor, 3-deazaadenosine, in the presence of homocysteine thiolactone, reduced cytotoxicity in a dose-dependent fashion. This effect was closely associated with inhibition of methylation of lipids but not of nucleic acids or proteins. The suggestion for a role of phospholipid methylation was supported by the observation that the interaction between NK-susceptible tumor targets and peripheral blood mononuclear cells caused increased phospholipid methylation only when susceptible target cells were used. Phospholipase A2 was also implicated in human NK activity. Inhibitors of the enzyme such as tetracaine, mepacrine, Rosenthal's inhibitor, and corticosteroids impaired NK function. Rosenthal's inhibitor was also shown to exert an inhibitory effect on a purified NK-cell population obtained by the isolation of large granular lymphocytes on Percoll gradients. Peripheral blood mononuclear cells were also directly shown to display phospholipase A2-like activity, as measured by the decrease in radioactive arachidonate from prelabeled phospholipids, specifically phosphatidylcholine, in effector cells. These data suggest that enhanced phospholipid methylation occurs during the recognition function of NK cells. Consequent activation of phospholipase A2 might be involved in the mechanisms leading to lytic events within the target cell.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	78
Language	English
Publisher	National Academy of Sciences
Publisher Date	1981-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytotoxicity, Immunologic Killer Cells, Natural Physiology Phospholipases A Metabolism Phospholipases Phospholipids Adrenal Cortex Hormones Pharmacology Arachidonic Acids Drug Effects Enzyme Activation Immunity, Cellular Methylation Phospholipases A2 Tubercidin Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in