NDLI: DNA double-strand breaks induced in normal human cells during the repair of ultraviolet light damage.

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DNA double-strand breaks induced in normal human cells during the repair of ultraviolet light damage.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bradley, M. O. Taylor, V. I.
Abstract	DNA double-strand breaks (DSBs) are formed in normal human IMR-90 cells during repair incubation after 100 and 300 J.m-2 of ultraviolet light. By contrast, no DSBs are formed after exposure to ultraviolet light in human XPA cells (from a patient with xeroderma pigmentosum complementation group A), which are unable to excise pyrimidine dimers. The DSBs are not due to immediate cell death, because all the cells excluded trypan blue at the time of assay and because XPA cells, which are much more sensitive to ultraviolet light than are IMR-90 cells, did not form DSBs after exposure to ultraviolet light. The DSBs do not appear to be due to either DNA synthesis or cellular single-strand endonucleases. We suggest that repair-induced DSBs would be potent lesions that might lead to cytotoxicity, chromosome aberrations, deletion mutations, and perhaps cellular transformation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	78
Language	English
Publisher	National Academy of Sciences
Publisher Date	1981-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Repair DNA Radiation Effects Ultraviolet Rays Cell Division Cells, Cultured Endonucleases Metabolism Models, Biological Xeroderma Pigmentosum Genetics Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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