NDLI: Immune response potential to poly(Tyr,Glu)-poly(DLAla)--poly(Lys) of human T cells of different donors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Katz, D. Bentwich, Z. Löwy, I. Mozes, E. Eshhar, N.
Abstract	Human peripheral blood T cells of normal donors were activated in vitro with autologous adherent cells pulsed with poly(LTyr,LGlu)-poly(DLAla)--poly(LLys) [abbreviated (T,G)-A--L]. The 'educated' T cells were tested: (i) for their ability to produce a (T,G)-A--L-specific T cell-replacing factor in the cooperation with B cells for antibody responses in vivo or in vitro and (ii) for their ability to proliferate in the presence of a second stimulus of (T,G)-A--L. Results of screening of 66 donors demonstrated that educated T cells of about 50% of the donors produced an active (T,G)-A--L-specific factor, whereas activated cells of only half of the factor producers were capable of proliferating in the presence of the antigen. Thus, as reported for all other species studied, human individuals differ in their response potential to (T,G)-A--L.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	78
Language	English
Publisher	National Academy of Sciences
Publisher Date	1981-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibody Formation Genes, MHC Class II Lymphocyte Cooperation Peptides Immunology T-Lymphocytes Epitopes Interleukin-1 Proteins Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Immune response potential to poly(Tyr,Glu)-poly(DLAla)--poly(Lys) of human T cells of different donors.