NDLI: Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

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Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

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Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Overbeek, P. A. Piatigorsky, J. Westphal, H. Chepelinsky, A. B. Khillan, J. S.
Abstract	Two lines of transgenic mice with one to two copies of a DNA fragment containing nucleotides -364 to +45 of the murine alpha A-crystallin gene linked to the bacterial chloramphenicol acetyltransferase (CAT) gene expressed the CAT gene only in their eye lenses. Both CAT activity and alpha A-crystallin were first detected in eyes at approximately 12.5 days of embryonic development, suggesting that the alpha A-CAT fusion gene and the endogenous alpha A-crystallin gene are co-regulated during lens development in the transgenic mice. These experiments show that the murine alpha A-crystallin gene contains a short, cis-acting, tissue-specific regulatory sequence at its 5' end that can target the expression of the bacterial CAT gene, and probably foreign eukaryotic genes, specifically to the ocular lens.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Crystallins Genetics Lens, Crystalline Physiology Promoter Regions, Genetic Acetyltransferases Animals Chloramphenicol O-Acetyltransferase DNA, Recombinant Gene Expression Regulation Genetic Engineering Embryology Mice RNA, Messenger Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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