NDLI: Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1985 Volume: 82 Issue: 24

Year: 1985 Volume: 82 Issue: 23

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100.

An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity.

Complexes of polyoma virus medium T antigen and cellular proteins.

Human group-specific component (Gc) is a member of the albumin family.

Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells.

Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin.

Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction.

DNA methylation at asymmetric sites is associated with numerous transition mutations.

Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region.

Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells.

Brain clathrin light chain 2 can be phosphorylated by a coated vesicle kinase.

Suppression of IgE secretion from hybridoma cells in allotype congenic mice: suppression of allotype 7a by T cells in allotype b mice.

Human beta-hexosaminidase alpha chain: coding sequence and homology with the beta chain.

Milrinone and thyroid hormone stimulate myocardial membrane Ca2+-ATPase activity and share structural homologies.

Characterization of the enzymatic lesion in inherited phosphofructokinase deficiency in the dog: an animal analogue of human glycogen storage disease type VII.

Class II major histocompatibility complex molecules regulate the development of the T4+T8- inducer phenotype of cultured human thymocytes.

Identification of the porcine intestinal 1,25-dihydroxyvitamin D3 receptor on sodium dodecyl sulfate/polyacrylamide gels by renaturation and immunoblotting.

Reconstitution of the GTP-dependent adenylate cyclase from products of the yeast CYR1 and RAS2 genes in Escherichia coli.

Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells.

Identification and some biochemical properties of the major XBL gene product of bovine leukemia virus.

Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation.

cDNA cloning of a human autoimmune nuclear ribonucleoprotein antigen.

Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon.

A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II.

Binding of pea cytochrome f to the inner membrane of Escherichia coli requires the bacterial secA gene product.

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

Expression of a cDNA encoding a functional 241-kilodalton vesicular stomatitis virus RNA polymerase.

Homologies between the Salmonella typhimurium CheY protein and proteins involved in the regulation of chemotaxis, membrane protein synthesis, and sporulation.

Activation of Na+/H+ exchange in cultured fibroblasts: synergism and antagonism between phorbol ester, Ca2+ ionophore, and growth factors.

Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle.

Polymorphic restriction endonuclease sites linked to the HLA-DR alpha gene: localization and use as genetic markers of insulin-dependent diabetes.

Transposase titration in Drosophila melanogaster: a model of cytotype in the P-M system of hybrid dysgenesis.

TnphoA: a transposon probe for protein export signals.

Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.

Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis.

Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: evidence for immunosuppressive effects and polyclonal B-cell activation by banded viral preparations.

The putative transforming protein of S13 avian erythroblastosis virus is a transmembrane glycoprotein with an associated protein kinase activity.

Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.

Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

Stereochemical course of the reaction catalyzed by the pyridoxal phosphate-dependent enzyme 1-aminocyclopropane-1-carboxylate synthase.

A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.

Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.

Structural requirements for sulfation of asparagine-linked oligosaccharides of lutropin.

Cloning and expression of cDNA for rat heme oxygenase.

Cloning of the human estrogen receptor cDNA.

Exposure of actin thiols by the removal of tightly held calcium ions.

Identification of a distinct soluble subunit of an intermediate filament protein: tetrameric vimentin from living cells.

Stabilization of the long central helix of troponin C by intrahelical salt bridges between charged amino acid side chains.

Ion etching bacteriophage T4: support for a spiral-fold model of packaged DNA.

Disulfide bond formation in the eye lens.

Primer-dependent eukaryotic RNA polymerase capable of accurate transcription from the adenovirus major late promoter in a reconstituted system.

Footprinting of ribosomal RNA genes by transcription initiation factor and RNA polymerase I.

Diethyl pyrocarbonate: a chemical probe for secondary structure in negatively supercoiled DNA.

Heat-resistant variants of Chinese hamster fibroblasts altered in expression of heat shock protein.

Myogenic growth factor present in skeletal muscle is purified by heparin-affinity chromatography.

Deposition-related histone acetylation in micronuclei of conjugating Tetrahymena.

Characterization of toposomes from sea urchin blastula cells: a cell organelle mediating cell adhesion and expressing positional information.

Cortical anomalies in brains of New Zealand mice: a neuropathologic model of dyslexia?

Structure, evolution, and regulation of a fast skeletal muscle troponin I gene.

Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit.

Cloning and chromosomal location of the alpha- and beta-globin genes from a marsupial.

Human monocyte-endothelial cell interaction in vitro.

1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow.

Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a metabolite that may induce differentiation of the human monoblastic cell line U937.

Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats.

A defect in cholesterol esterification in Niemann-Pick disease (type C) patients.

Depolarization regulates adrenal preproenkephalin mRNA.

Differentiation of neuronal growth cones: specialization of filopodial tips for adhesive interactions.

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.

Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype.

Interleukin 1 can act as a B-cell growth and differentiation factor.

Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli.

Anti-peptide antibodies detect oncogene-related proteins in urine.

Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissues.

Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.

Mechanism of action of the group A streptococcal C5a inactivator.

Isolation of cDNA clones encoding a T-cell receptor beta-chain from a beef insulin-specific hybridoma.

Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens.

Characterization of pituitary calcium-activated, phospholipid-dependent protein kinase: redistribution by gonadotropin-releasing hormone.

The subsynaptic 43-kDa protein is concentrated at developing nerve-muscle synapses in vitro.

Construction of strains of Saccharomyces cerevisiae that grow on lactose.

Confirmation of the assignment of the low-field proton resonance of serine proteases by using specifically nitrogen-15 labeled enzyme.

Repair-defect mutations inhibit rDNA magnification in Drosophila and discriminate between meiotic and premeiotic magnification.

Catabolite-resistant sporulation (crsA) mutations in the Bacillus subtilis RNA polymerase sigma 43 gene (rpoD) can suppress and be suppressed by mutations in spo0 genes.

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

Regulation of expression of the human interferon gamma gene.

Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid.

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin.

Year: 1985 Volume: 82 Issue: 22

Year: 1985 Volume: 82 Issue: 21

Year: 1985 Volume: 82 Issue: 20

Year: 1985 Volume: 82 Issue: 19

Year: 1985 Volume: 82 Issue: 18

Year: 1985 Volume: 82 Issue: 17

Year: 1985 Volume: 82 Issue: 16

Year: 1985 Volume: 82 Issue: 15

Year: 1985 Volume: 82 Issue: 14

Year: 1985 Volume: 82 Issue: 13

Year: 1985 Volume: 82 Issue: 12

Year: 1985 Volume: 82 Issue: 11

Year: 1985 Volume: 82 Issue: 10

Year: 1985 Volume: 82 Issue: 9

Year: 1985 Volume: 82 Issue: 8

Year: 1985 Volume: 82 Issue: 7

Year: 1985 Volume: 82 Issue: 6

Year: 1985 Volume: 82 Issue: 5

Year: 1985 Volume: 82 Issue: 4

Year: 1985 Volume: 82 Issue: 3

Year: 1985 Volume: 82 Issue: 2

Year: 1985 Volume: 82 Issue: 1

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hannink, M. Donoghue, D. J.
Abstract	The transforming gene product encoded by Moloney murine sarcoma virus clone 124, p37mos, contains a lysine residue (lysine-121) that is conserved among all members of the protein kinase family. This lysine has been shown to be part of a conserved ATP-binding site in both the catalytic subunit of the cAMP-dependent protein kinase and p60v-src. We wished to determine whether this lysine is required for the transforming activity of p37mos. Two site-specific mutations were therefore constructed, which result in the substitution of an aspartic acid or arginine codon in place of the codon for lysine-121. Both mutations abolished the ability of the mos gene to transform cells. These results show that lysine-121 is required for the ability of p37mos to transform cells and provide evidence for an ATP-binding site in p37mos. Furthermore, these results suggest that the conserved lysine residue is specifically involved in the catalytic activity of protein kinases in general.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenosine Triphosphate Metabolism Cell Transformation, Viral Moloney Murine Sarcoma Virus Genetics Oncogene Proteins, Viral Protein Kinases Sarcoma Viruses, Murine Amino Acid Sequence Animals Binding Sites Cell Line Cercopithecus Aethiops Lysine Molecular Weight Mutation Structure-Activity Relationship Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in