NDLI: Characterization of a cDNA coding for human factor VII.

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Characterization of a cDNA coding for human factor VII.

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Characterization of a cDNA coding for human factor VII.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hagen, F. S. Gray, C. L. Grant, F. J. Saari, G. C. O'hara, P. Hart, C. E. Woodbury, R. G. Kurachi, K. Kisiel, W. Insley, M.
Abstract	Factor VII is a precursor to a serine protease that is present in mammalian plasma. In its activated form, it participates in blood coagulation by activating factor X and/or factor IX in the presence of tissue factor and calcium. Clones coding for factor VII were obtained from two cDNA libraries prepared from poly(A) RNA from human liver and Hep G2 cells. The amino acid sequence deduced from the cDNAs indicates that factor VII is synthesized with a prepro-leader sequence of 60 or 38 amino acids. The mature protein that circulates in plasma is a single-chain polypeptide composed of 406 amino acids. The amino acid sequence analysis of the protein and the amino acid sequence deduced from the cDNAs indicate that factor VII is converted to factor VIIa by the cleavage of a single internal bond between arginine and isoleucine. This results in the formation of a light chain (152 amino acids) and a heavy chain (254 amino acids) that are held together by a disulfide bond. The light chain contains a gamma-carboxyglutamic acid (Gla) domain and two potential epidermal growth factor domains, while the heavy chain contains the serine protease portion of the molecule. Factor VII shows a high degree of amino acid sequence homology with the other vitamin K-dependent plasma proteins.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Factor VII Genetics Amino Acid Sequence Calcium-Binding Proteins Cloning, Molecular DNA Gene Expression Regulation Genetic Vectors Growth Substances Osteocalcin Protein Sorting Signals Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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