NDLI: Molecular cloning of a functional bovine interleukin 2 cDNA.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1986 Volume: 83 Issue: 24

Year: 1986 Volume: 83 Issue: 23

Year: 1986 Volume: 83 Issue: 22

Year: 1986 Volume: 83 Issue: 21

Year: 1986 Volume: 83 Issue: 20

Year: 1986 Volume: 83 Issue: 19

Year: 1986 Volume: 83 Issue: 18

Year: 1986 Volume: 83 Issue: 17

Year: 1986 Volume: 83 Issue: 16

Year: 1986 Volume: 83 Issue: 15

Year: 1986 Volume: 83 Issue: 14

Year: 1986 Volume: 83 Issue: 13

Year: 1986 Volume: 83 Issue: 12

Year: 1986 Volume: 83 Issue: 11

Year: 1986 Volume: 83 Issue: 10

Stable accumulation of a rat truncated repeat transcript in Xenopus oocytes.

Human prostate-specific antigen: structural and functional similarity with serine proteases.

Kinetic diagram and free energy diagram for kinesin in microtubule-related motility.

Self and non-self discrimination by 'restriction proteases'.

Lectin activity as a marker for Hodgkin disease cells.

Location of the major antigenic sites involved in rotavirus serotype-specific neutralization.

Brain-specific hyaluronate-binding protein: an immunohistological study with monoclonal antibodies of human and bovine central nervous system.

Voltage- and time-dependent effects of phencyclidines on the endplate current arise from open and closed channel blockade.

Isolated plasma membranes regulate neurotransmitter expression and facilitate effects of a soluble brain cholinergic factor.

Human peripheral monocytes express putative receptors for neuroexcitatory amino acids.

Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes.

Methyl-directed repair of frameshift mutations in heteroduplex DNA.

T cells can be cytotoxic without making interleukin 2: a model of separate pathways of induction.

Rate of force generation in muscle: correlation with actomyosin ATPase activity in solution.

The chicken delta 1-crystallin gene promoter: binding of transcription factor(s) to the upstream G+C-rich region is necessary for promoter function in vitro.

Transcriptional 'silencer' element in rat repetitive sequences associated with the rat insulin 1 gene locus.

Superoxide mediates the toxicity of paraquat for Chinese hamster ovary cells.

Activation of gene expression is adversely affected at high multiplicities of linked simian virus 40 enhancer.

Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogeneity.

Activation of rat c-raf during transfection of hepatocellular carcinoma DNA.

Transcriptional activation encoded by the v-fos gene.

Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes.

Specific binding of human corticosteroid-binding globulin to cell membranes.

A block in initiation of simian virus 40 assembly results in the accumulation of minichromosomes containing an exposed regulatory region.

Retroviral mutants efficiently expressed in embryonal carcinoma cells.

Specific binding of the mononuclear phagocyte colony-stimulating factor CSF-1 to the product of the v-fms oncogene.

Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius.

Atrial natriuretic factor receptors in rat kidney, adrenal gland, and brain: autoradiographic localization and fluid balance dependent changes.

HLA-DR2, -DR5, and DRw6 associated Dw subtypes correlate with HLA-DR beta and -DQ beta restriction fragment length polymorphisms.

Tissue tropism of a leukemogenic murine retrovirus is determined by sequences outside of the long terminal repeats.

The qa repressor gene of Neurospora crassa: wild-type and mutant nucleotide sequences.

Illegitimate recombination at the replication origin of bacteriophage M13.

DNA linkage analysis of X chromosome-linked chronic granulomatous disease.

Chemically induced mutagenesis in a shuttle vector with a low-background mutant frequency.

Effect of atrial natriuretic peptide on gonadotropin release in superfused rat pituitary cells.

Restriction fragment length polymorphism caused by a deletion within the human c-abl gene (ABL).

Class I histocompatibility antigens and insulin receptors: evidence for interactions.

Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro.

Synaptophysin: a marker protein for neuroendocrine cells and neoplasms.

Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus.

Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: effects on cyclic GMP production.

Genetic uniformity in two populations of Drosophila melanogaster as revealed by filter hybridization of four-nucleotide-recognizing restriction enzyme digests.

Biphasic effects of estrogen on apolipoprotein synthesis in human hepatoma cells: mechanism of antagonism by testosterone.

Identification of a positive retroregulator that stabilizes mRNAs in bacteria.

Tumor cell autocrine motility factor.

Trans-acting amplification mutants and other eggshell mutants of the third chromosome in Drosophila melanogaster.

Photoreactivation rescue and hypermutability of ultraviolet-irradiated excisionless Drosophila melanogaster larvae.

Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.

Influence of delayed immune reactions on human epidermal keratinocytes.

Low-dimensional chaos in an instance of epilepsy.

Sensitivity of gap junctional conductance to H ions in amphibian embryonic cells is independent of voltage sensitivity.

A model-based approach for estimating the mean incubation period of transfusion-associated acquired immunodeficiency syndrome.

Agreement with the disulfide stretching frequency-conformation correlation of Sugeta, Go, and Miyazawa.

An alternative technique for the computation of the designator in the retinex theory of color vision.

Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding.

Cloning and sequence analysis of cDNA species coding for the two subunits of inhibin from bovine follicular fluid.

A mouse tumor-specific transplantation antigen is a heat shock-related protein.

Phorbol diesters inhibit enzymatic hydrolysis of diacylglycerols in vitro.

Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.

Gene for lysine tRNA1 may be a progenitor of the highly repetitive and transcribable sequences present in the salmon genome.

Human inhibitor of the first component of complement, C1: characterization of cDNA clones and localization of the gene to chromosome 11.

Binding of thymopoietin to the acetylcholine receptor.

Construction and characterization of the alpha form of a cardiac myosin heavy chain cDNA clone and its developmental expression in the Syrian hamster.

Human histone genes map to multiple chromosomes.

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

Regulation of bacteriophage P2 late-gene expression: the ogr gene.

Analysis of a sea urchin gene cluster coding for the small nuclear U7 RNA, a rare RNA species implicated in the 3' editing of histone precursor mRNAs.

Controlling the pKa of the bacteriorhodopsin Schiff base by use of artificial retinal analogues.

Distribution of ions around DNA, probed by energy transfer.

The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated beta-sheet.

A proton NMR study of the mechanism of the erythrocyte glucose transporter.

Exocrine secretion granules contain peptide amidation activity.

Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages.

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts.

Structure and developmentally regulated expression of a Strongylocentrotus purpuratus collagen gene.

Efficient recovery and sequencing of mutant genes from mammalian chromosomal DNA.

Mitotic recombination in germ cells generated two major histocompatibility complex mutant genes shown to be identical by RNA sequence analysis: Kbm9 and Kbm6.

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

Protease and cyclooxygenase inhibitors synergistically prevent activation of human platelets.

Metabolism of lipoproteins containing apolipoprotein B-100 in blood plasma of rabbits: heterogeneity related to the presence of apolipoprotein E.

Stable expression of selectable genes introduced into human hematopoietic stem cells by electric field-mediated DNA transfer.

A defined system for in vitro packaging of DNA-gp3 of the Bacillus subtilis bacteriophage phi 29.

Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.

Selection and amplification of heterologous genes encoding adenosine deaminase in mammalian cells.

Molecular cloning of a functional bovine interleukin 2 cDNA.

Characterization, mapping, and expression of the human ceruloplasmin gene.

Suppression of lymphocyte activation and functions by a leukemia cell-derived inhibitor.

Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.

Fusion of renal epithelial cells: a model for studying cellular mechanisms of ion transport.

A mutation that prevents glucosylation of the lipid-linked oligosaccharide precursor leads to underglycosylation of secreted yeast invertase.

Secretion and autoproteolytic maturation of subtilisin.

Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells.

Homology between RNA polymerases of poxviruses, prokaryotes, and eukaryotes: nucleotide sequence and transcriptional analysis of vaccinia virus genes encoding 147-kDa and 22-kDa subunits.

Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells.

Cloning, sequence, and expression of bovine interleukin 2.

Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene.

Platelets contain a peptide inhibitor of endothelial cell replication and growth.

Cell specificity and an effect of ras on human metallothionein gene expression.

Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome.

Monoclonal antibodies to HLA-DP-transfected mouse L cells.

Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia.

Human seminal alpha-inhibins: detection in human pituitary, hypothalamus, and serum by immunoreactivity.

Protease-induced immunoregulatory activity of platelet factor 4.

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.

Year: 1986 Volume: 83 Issue: 9

Year: 1986 Volume: 83 Issue: 8

Year: 1986 Volume: 83 Issue: 7

Year: 1986 Volume: 83 Issue: 6

Year: 1986 Volume: 83 Issue: 5

Year: 1986 Volume: 83 Issue: 4

Year: 1986 Volume: 83 Issue: 3

Year: 1986 Volume: 83 Issue: 2

Year: 1986 Volume: 83 Issue: 1

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Molecular cloning of a functional bovine interleukin 2 cDNA.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barr, P. J. Nissen, M. S. Magnuson, J. A. Reeves, R. Magnuson, N. S. Weinberg, A. D. Buck, C. D. Spies, A. G.
Abstract	A cDNA clone of the bovine interleukin 2 (IL-2) gene has been isolated and demonstrated to be functional in the production of secreted bovine IL-2 protein when transfected into monkey cells. The bovine IL-2 clone is 791 base pairs in length and contains an open reading frame of 474 base pairs coding for a bovine IL-2 precursor polypeptide of 158 amino acids with an estimated molecular weight of 17,884. The putative hydrophobic leader or signal sequence of the precursor protein is 23 amino acid residues long, suggesting that, after removal by processing, the mature secreted bovine IL-2 protein contains 135 amino acids and has a molecular weight of 15,464. Comparisons of both the nucleotide sequence and the predicted amino acid sequence of bovine IL-2 with those of the human and mouse IL-2 show extensive regions of sequence conservation between the species, interspersed with other regions of less similarity. The 3' untranslated region of the bovine IL-2 gene shares as much, if not greater, sequence homology with the 3' untranslated regions of the human and mouse genes as do the transcribed coding regions of these genes, suggesting an involvement of this region in regulation. In particular, a tandemly repeated sequence, (TATT)n, found in the 3' untranslated tail of the bovine IL-2 clone is also found in the 3' untranslated region of the other known interleukin and interferon genes, as well as in similar regions of many other inducible genes of the lymphoid and immune response systems, suggesting a cell or tissue-specific regulatory function for these evolutionarily conserved sequences.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Interleukin-2 Genetics Amino Acid Sequence Animals Cell Line Cercopithecus Aethiops Cloning, Molecular DNA Gene Expression Regulation Genes RNA, Messenger Sequence Homology, Nucleic Acid Solubility Comparative Study Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in