NDLI: Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene.

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Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene.

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Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Okumoto, D. S. Hanawalt, P. C. Bohr, V. A.
Abstract	The survival of UV-irradiated mammalian cells is not necessarily correlated with their overall capacity to carry out DNA repair. Human cells typically remove 80% of the pyrimidine dimers produced by a UV dose of 5 J/m2 within 24 hr. In contrast, a Chinese hamster ovary (CHO) cell line survives UV irradiation equally well while removing only 15% of the dimers. Using a newly developed technique to measure dimer frequencies in single-copy specific sequences, we find that the CHO cells remove 70% of the dimers from the essential dihydrofolate reductase (DHFR) gene but only 20% from sequences located 30 kilobases or more upstream from the 5' end of the gene in a 24-hr period. Repair-deficient human cells from xeroderma pigmentosum complementation group C (XPC) are similar to the CHO cells in overall repair levels, but they are extremely sensitive to killing by UV irradiation. In the XPC cells, we find little or no repair in the DHFR gene; in contrast, in normal human fibroblasts and epidermal keratinocytes, greater than 80% of the dimers induced in the gene by 20 J/m2 are removed in 24 hr. Since the CHO and normal human cells exhibit similar UV resistance, much higher than that of XPC cells, our findings suggest a correlation between efficient repair of essential genes and resistance to DNA-damaging agents such as UV light.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Repair Tetrahydrofolate Dehydrogenase Genetics Ultraviolet Rays Animals Cell Survival Radiation Effects Cells, Cultured Cricetinae Genes Pyrimidine Dimers Metabolism Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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