NDLI: Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C.

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Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C.

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Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baraban, J. M. Worley, P. F. De Souza, E. B. Snyder, S. H.
Abstract	[3H]Forskolin and [3H]phorbol 12,13-dibutyrate have been used to map the adenylate cyclase and phosphatidylinositol systems respectively in brain slices by light-microscopic autoradiography. [3H]Forskolin binding to brain sections is displaced potently by forskolin (KD approximately equal to 15 nM) and is enhanced by fluoride and GTP analogs, agents which activate the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Highest [3H]forskolin binding occurs in the corpus striatum, substantia nigra, hippocampus, and molecular layer of the cerebellum. Lesion studies demonstrate that binding sites in the substantia nigra are associated with striatal afferents, while hippocampal sites are localized to granule cell dendrites and mossy fiber terminals, and the intense binding in the cerebellar molecular layer is largely associated with granule cell axons and terminals. Protein kinase C mediates the activity of hormones and neurotransmitters, which act through the phosphatidylinositol cycle, and is labeled with high affinity by [3H]phorbol 12,13-dibutyrate. At many synapses, maps of adenylate cyclase and protein kinase C reveal reciprocal distributions, which may have implications for second messenger regulation of synaptic transmission.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenylate Cyclase Metabolism Brain Enzymology Protein Kinase C Animals Autoradiography Binding Sites Anatomy & Histology Brain Mapping Cerebellum Colforsin Hippocampus Kainic Acid Pharmacology Phorbol Esters Quinolinic Acid Quinolinic Acids Synaptic Transmission Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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