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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jimenez, S. A. French, B. T. Maul, G. G. Van Venrooij, W. J. |
| Abstract | Antibodies derived from scleroderma patients positive for the extractable 70-kDa antigen were shown to react with topoisomerase I. Topoisomerase I was identified by molecular size and by antibody inhibition of the topoisomerase I-specific relaxation of supercoiled plasmid DNA. By using in situ localization by indirect fluorescence, we found topoisomerase I preferentially located in the centromeric regions of the mouse G2-phase cells and chromosomes, while the distribution in human cells is much more dispersed. Moreover, comparison of a published consensus sequence for topoisomerase I binding with mouse satellite DNA revealed a high degree of homology. The localization of topoisomerase I in the centromeres of mouse cells in the later part of the cell cycle and prior to anaphase suggests functional involvement in mitosis. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 83 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1986-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Centromere Chromosomes DNA Topoisomerases, Type I Interphase Nuclear Proteins Animals Antibody Specificity Autoantibodies Immunology Cell Line Fluorescent Antibody Technique HeLa Cells Isoelectric Point Mice Mitosis Molecular Weight Nucleoproteins Isolation & Purification Scleroderma, Systemic Sequence Homology, Nucleic Acid Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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