NDLI: Cyclosporin A prevents induction of the interleukin 2 receptor gene in cultured murine thymocytes.

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Cyclosporin A prevents induction of the interleukin 2 receptor gene in cultured murine thymocytes.

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Cyclosporin A prevents induction of the interleukin 2 receptor gene in cultured murine thymocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Khandjian, E. W. Gauchat, J. F. Weil, R.
Abstract	Blast formation and mitotic activation of G0-arrested mouse thymocytes were triggered by the addition of concanavalin A plus interleukin 2 (IL-2) to the culture medium. When added alone, Con A induces within 6 hr a complex reprogramming ('priming') that comprises the activation of the IL-2 receptor gene. The primed thymocytes are competent to interact with IL-2 and to respond to its growth-promoting effect, which corresponds to blast formation and mitotic activation. Cyclosporin A, an immunosuppressive cyclic peptide of fungal origin, prevents in T lymphocytes the activation of a set(s) of genes encoding lymphokines and the IL-2 receptor but does not affect their expression once they have been activated. The biomedical implications of these observations are discussed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cyclosporins Pharmacology Interleukin-2 Physiology Receptors, Immunologic Biosynthesis T-Lymphocytes Drug Effects Animals DNA Gene Expression Regulation Lymphocyte Activation Mice Mice, Inbred BALB C Protein Biosynthesis RNA RNA, Messenger Genetics Receptors, Interleukin-2 Thymus Gland Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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