Cyclosporin A prevents induction of the interleukin 2 receptor gene in cultured murine thymocytes.

Content Provider	Semantic Scholar
Author	Gauchat, Jean François Khandjian, Édouard W. Weil, Robert
Copyright Year	1986
Abstract	Blast formation and mitotic activation of G0-arrested mouse thymocytes were triggered by the addition of concanavalin A plus interleukin 2 (IL-2) to the culture medium. When added alone, Con A induces within 6 hr a complex reprogramming ("priming") that comprises the activation of the IL-2 receptor gene. The primed thymocytes are competent to interact with IL-2 and to respond to its growth-promoting effect, which corresponds to blast formation and mitotic activation. Cyclosporin A, an immunosuppressive cyclic peptide of fungal origin, prevents in T lymphocytes the activation of a set(s) of genes encoding lymphokines and the IL-2 receptor but does not affect their expression once they have been activated. The biomedical implications of these observations are discussed.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.83.17.6430
PubMed reference number	2428033
Journal	Medline
Volume Number	83
Issue Number	17
Alternate Webpage(s)	http://www.pnas.org/content/83/17/6430.full.pdf
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article