NDLI: Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1986 Volume: 83 Issue: 24

Parallel packing of alpha-helices in crystals of the zervamicin IIA analog Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe.2H2O.

Improved free-energy parameters for predictions of RNA duplex stability.

Human autoantibodies reactive with the signal-recognition particle.

Allelic variation in human mitochondrial genes based on patterns of restriction site polymorphism.

Evidence for reactive oxygen species inducing mutations in mammalian cells.

Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein.

Antibodies to the binding site of the receptor for luteinizing hormone-releasing hormone (LHRH): generation with a synthetic decapeptide encoded by an RNA complementary to LHRH mRNA.

Human beta-melanocyte-stimulating hormone revisited.

Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses.

Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.

Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells.

The homeo domain of a murine protein binds 5' to its own homeo box.

Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma.

Molecular studies of murine mutant BALB/c-H-2dm2 define a deletion of several class I genes including the entire H-2Ld gene.

Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain.

Release of neuropeptides during intracellular stimulation of single identified Aplysia neurons in culture.

Hormonal modulation of the quantity and in situ activity of tyrosine hydroxylase in neurites of the median eminence.

Isolation of pyroGlu-Gly-Arg-Phe-NH2 (Antho-RFamide), a neuropeptide from sea anemones.

High-affinity fluorescent peptide binding to I-Ad in lipid membranes.

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide.

Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae.

Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species.

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase.

Polarized expression of a chimeric protein in which the transmembrane and cytoplasmic domains of the influenza virus hemagglutinin have been replaced by those of the vesicular stomatitis virus G protein.

Angiotensin-stimulated production of inositol trisphosphate isomers and rapid metabolism through inositol 4-monophosphate in adrenal glomerulosa cells.

Photoaffinity labeling of the porcine brain alpha 2-adrenergic receptor using a radioiodinated arylazide derivative of rauwolscine: identification of the hormone-binding subunit.

Two DNA recognition domains of the specificity polypeptides of a family of type I restriction enzymes.

Diacylglycerol-induced translocation of diacylglycerol kinase: use of affinity-purified enzyme in a reconstitution system.

Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells.

Structural analysis of a rat liver glutathione S-transferase Ya gene.

Phosphatidylinositol from ethanol-fed rats confers membrane tolerance to ethanol.

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

Actin-severing activity copurifies with phosphofructokinase.

2-(N-acetoxy-N-acetylamino)fluorene mutagenesis in mammalian cells: sequence-specific hot spot.

Molecular cloning, encoding sequence, and expression of vaccinia virus nucleic acid-dependent nucleoside triphosphatase gene.

Molecular analysis of the maize anthocyanin regulatory locus C1.

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.

Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.

Identification of an activated c-Ki-ras oncogene in rat liver tumors induced by aflatoxin B1.

Alternative splicing generates two distinct Eip28/29 gene transcripts in Drosophila Kc cells.

New RNA polymerase sigma factor under spo0 control in Bacillus subtilis.

Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes.

Mutational analysis of the immunoglobulin heavy chain promoter region.

Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor.

Monocyte migration explains the changes in macrophage arachidonate metabolism during the immune response.

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

Long-term modulation of Ca2+-stimulated autophosphorylation and subcellular distribution of the Ca2+/calmodulin-dependent protein kinase in the brain of Drosophila.

Current issues in developing a strategy for dealing with the acquired immunodeficiency syndrome.

Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle.

Regulation of insulin-like growth factor I gene expression by growth hormone.

Activation of transcription by the bacteriophage 434 repressor.

Hemoglobin S Antilles: a variant with lower solubility than hemoglobin S and producing sickle cell disease in heterozygotes.

The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA.

Evaluation of methods for the prediction of membrane protein secondary structures.

Ornithine decarboxylase from mouse epidermis and epidermal papillomas: differences in enzymatic properties and structure.

Multiple controls of oxidative metabolism in living tissues as studied by phosphorus magnetic resonance.

Sequential state generation by model neural networks.

Dynamic exchange of myosin molecules between thick filaments.

Fluid phase endocytosis by cultured rat hepatocytes and perfused rat liver: implications for plasma membrane turnover and vesicular trafficking of fluid phase markers.

Phosphorylation of the secreted, free alpha subunit of human chorionic gonadotropin.

Activation of the multifunctional Ca2+/calmodulin-dependent protein kinase by autophosphorylation: ATP modulates production of an autonomous enzyme.

Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton.

Tissue-specific transcription enhancement of the fibroin gene characterized by cell-free systems.

Regulation of pulmonary surfactant apoprotein SP 28-36 gene in fetal human lung.

Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells.

Behavioral facilitation of reproduction in sexual and unisexual whiptail lizards.

Mitochondrial DNA analysis of hybridization between sympatric white-tailed deer and mule deer in west Texas.

Ability of RecA protein to promote a search for rare sequences in duplex DNA.

Rapid plasmid library screening using RecA-coated biotinylated probes.

Systemic resistance to methotrexate in transgenic mice carrying a mutant dihydrofolate reductase gene.

Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.

Identification of the major mannose-binding proteins from chicken egg yolk and chicken serum as immunoglobulins.

Tumorigenicity of hamster and mouse cells transformed by adenovirus types 2 and 5 is not influenced by the level of class I major histocompatibility antigens expressed on the cells.

Morphological alterations in endothelial cells from human aorta and umbilical vein induced by forskolin and phorbol 12-myristate 13-acetate: a synergistic action of adenylate cyclase and protein kinase C activators.

Transvenous coronary angiography in humans using synchrotron radiation.

Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells.

Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease.

Morphine and codeine from mammalian brain.

Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists.

Individual exons encode the integral membrane domains of human myelin proteolipid protein.

Evidence on precise time-coded symbols and memory of patterns in monkey cortical neuronal spike trains.

cDNA clones of the neural cell adhesion molecule (N-CAM) lacking a membrane-spanning region consistent with evidence for membrane attachment via a phosphatidylinositol intermediate.

Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression.

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

HLA antigens expressed on murine cells are preferentially recognized by murine cytotoxic T cells in the context of the H-2 major histocompatibility complex.

Cross-reactivity to human T-lymphotropic virus type III/lymphadenopathy-associated virus and molecular cloning of simian T-cell lymphotropic virus type III from African green monkeys.

New scientific opportunities and old obstacles in vaccine development.

Nucleotide binding by a 24-residue peptide from the RecA protein of Escherichia coli.

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

Promoter domain mediates guanosine tetraphosphate activation of the histidine operon.

Stimulation of human neuroblastoma DNA polymerase alpha and primase activities by a protein factor isolated from rat liver chromatin.

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

Conserved protein domains in a myosin heavy chain gene from Dictyostelium discoideum.

Synthesis, bacterial expression, and mutagenesis of the gene coding for mammalian cytochrome b5.

Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.

Expression of human HSP70 during the synthetic phase of the cell cycle.

Direct introduction of genes into rats and expression of the genes.

Rho-dependent transcription termination of a bacterial operon is antagonized by an extrachromosomal gene product.

Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.

Isolation of a cDNA for human acid alpha-glucosidase and detection of genetic heterogeneity for mRNA in three alpha-glucosidase-deficient patients.

Positive and negative roles of an initiator protein at an origin of replication.

Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells.

T-cell receptor alpha-chain gene is split in a human T-cell leukemia cell line with a t(11;14)(p15;q11).

Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate.

Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

Year: 1986 Volume: 83 Issue: 23

Year: 1986 Volume: 83 Issue: 22

Year: 1986 Volume: 83 Issue: 21

Year: 1986 Volume: 83 Issue: 20

Year: 1986 Volume: 83 Issue: 19

Year: 1986 Volume: 83 Issue: 18

Year: 1986 Volume: 83 Issue: 17

Year: 1986 Volume: 83 Issue: 16

Year: 1986 Volume: 83 Issue: 15

Year: 1986 Volume: 83 Issue: 14

Year: 1986 Volume: 83 Issue: 13

Year: 1986 Volume: 83 Issue: 12

Year: 1986 Volume: 83 Issue: 11

Year: 1986 Volume: 83 Issue: 10

Year: 1986 Volume: 83 Issue: 9

Year: 1986 Volume: 83 Issue: 8

Year: 1986 Volume: 83 Issue: 7

Year: 1986 Volume: 83 Issue: 6

Year: 1986 Volume: 83 Issue: 5

Year: 1986 Volume: 83 Issue: 4

Year: 1986 Volume: 83 Issue: 3

Year: 1986 Volume: 83 Issue: 2

Year: 1986 Volume: 83 Issue: 1

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Batist, G. Cowan, K. H. Sinha, B. K. Tulpule, A. Myers, C. E.
Abstract	MCF7 human breast cancer cells selected for resistance to doxorubicin (adriamycin; DoxR) have developed the phenotype of multidrug resistance. Multidrug resistance in DoxR MCF7 cells (called AdrR MCF7 cell line in previous publications) is associated with biochemical changes similar to those induced by carcinogens in rat hyperplastic liver nodules (HNs) and associated with resistance to xenobiotics in that system. In HNs and DoxR cells, exposure to a single agent results in the selection of cells that are cross-resistant to a wide variety of structurally dissimilar toxic agents. Resistance in both systems is associated with decreases in intracellular accumulation of toxins and changes in phase I (decreased cytochrome P1-450) and phase II (increased glutathione transferase and glucuronyltransferase) drug-metabolizing activities. In HNs and DoxR cells, resistance is associated with the induction of relatively stable levels of an immunologically related anionic glutathione transferase isozyme (EC 2.5.1.18). The finding of similar biochemical changes associated with the development of resistance to various xenobiotics in HNs and to many naturally occurring antineoplastic agents and at least one carcinogen (benzo[a]pyrene) in DoxR MCF7 cells suggests that the mechanisms of resistance in these two models may be similar.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Pharmacology Drug Resistance Animals Biotransformation Breast Neoplasms Metabolism Cell Line Cytochrome P-450 Enzyme System Genetics Gene Expression Regulation Glutathione Transferase Immunologic Techniques Mixed Function Oxygenases Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in