NDLI: Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons.

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Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons.

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Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peterson, S. W. Kyriakis, J. M. Hausman, R. E.
Description	Author Affiliation: Kyriakis JM ( Biological Sciences Center, Boston University, MA 02215.);
Abstract	The effect of insulin on the appearance of the enzyme choline acetyltransferase (ChoAcT; acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6) in embryonic chicken retina neurons cultured in defined medium was studied. In the presence of a minimal level of insulin (1 ng/ml), ChoAcT activity increased with time in culture. A correspondence between the insulin concentration in the defined medium (1-100 ng/ml) and both the rate of increase and maximum attained level of ChoAcT activity was observed. Maximal ChoAcT activity was 2- to 3-fold greater in cells cultured in the presence of 100 ng of insulin per ml than in cells cultured in the presence of 1 ng of insulin per ml. To elicit maximum ChoAcT activity, insulin at 100 ng/ml was required in the medium for only the first 4 days of the culture period, at which time insulin could be reduced to maintenance levels (10 ng/ml) without affecting ChoAcT activity. Insulin binding assays performed during a 7-day culture period revealed that irrespective of the insulin concentration in the medium during culture, cell-surface insulin receptors decreased by approximately 90% between 4 and 7 days in culture. This decrease in insulin binding corresponded to the observed decrease in the sensitivity of ChoAcT activity to insulin. Our findings suggest that insulin plays a role in mediating cholinergic differentiation in the embryonic chicken retina.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	84
Language	English
Publisher	National Academy of Sciences
Publisher Date	1987-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Choline O-Acetyltransferase Metabolism Insulin Pharmacology Receptor, Insulin Retina Enzymology Retinal Ganglion Cells Animals Binding, Competitive Cells, Cultured Chick Embryo Analogs & Derivatives Kinetics Embryology Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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