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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Krust, A. Schiff, V. Gairard, B. Calderoli, H. Renaud, R. Koehl, C. Rio, M. C. Bellocq, J. P. Rasmussen, U. B. Chambon, P. |
| Description | Author Affiliation: Rio MC ( Laboratoire de Génétique Moléculaire, Centre National de la Recherche Scientifique et U. 184, Faculté de Médecine, Strasbourg, France.); |
| Abstract | The expression of the pS2 gene, which is induced by estrogen in the breast cancer cell line MCF-7, has been investigated in breast cancers by using pS2 mRNA determination in tumor specimens and immunocytochemistry to identify pS2 protein in paraffin-embedded sections. Using these assays we show that determination of pS2 gene expression allows the definition of subclasses of estrogen-receptor-containing breast cancers that may be used to more precisely identify estrogen-dependent tumors. Tumor specimens have also been analyzed for the presence of mRNAs for the estrogen receptor and for the ERBB2 oncogene. No evidence for the presence of truncated forms of estrogen-receptor mRNA has been found, and overexpression of the ERBB2 oncogene did not correlate with the steroid receptor status or pS2 gene expression. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 84 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1987-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Breast Neoplasms Genetics DNA, Neoplasm Neoplasm Proteins Oncogenes Receptors, Estrogen Receptors, Progesterone Gene Expression Regulation Immunoenzyme Techniques RNA, Messenger RNA, Neoplasm Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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