NDLI: A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.

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A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.

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A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barza, M. Wolff, S. M. Van Der Meer, J. W. Dinarello, C. A.
Description	Author Affiliation: van der Meer JW ( Department of Medicine, Tufts University School of Medicine-New England Medical Center, Boston, MA 02111.);
Abstract	Natural and synthetic immunomodulators that increase nonspecific resistance to infection induce interleukin 1 (IL-1) production. Therefore, we investigated the effect of the administration of IL-1 on the survival of lethally infected granulocytopenic mice. Mice with cyclophosphamide-induced granulocytopenia were injected with approximately 10(7) Pseudomonas aeruginosa in the thigh muscle at time 0; gentamicin was administered 6 hr and 23 hr later. When recombinant human IL-1 beta (one of the two forms of IL-1) was given as a single i.p. injection 24 hr before the infection, survival was increased. Using 80 ng of IL-1 beta per mouse, survival compared to control animals was 98% vs. 71% at 24 hr, 98% vs. 60% at 30 hr, 86% vs. 36% at 36 hr, and 61% vs. 11% at 48 hr (P less than 0.001) after the infection. No effect of IL-1 was observed when it was given 0.5 hr before or 6 hr after the infection. Animals not treated with gentamicin also benefited from the IL-1. Administration of the cyclooxygenase inhibitor ibuprofen did not affect the activity of IL-1. Numbers of bacteria cultured from the blood, thigh muscle, liver, spleen, and kidney were similar in IL-1-treated and control animals. Superoxide production by peritoneal macrophages was also similar in the two groups. These studies demonstrate that IL-1 pretreatment protects granulocytopenic mice against lethal pseudomonas infection and suggest that this protection occurs through a noncellular mechanism.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Agranulocytosis Immunology Interleukin-1 Therapeutic Use Pseudomonas Infections Therapy Recombinant Proteins Streptococcal Infections Animals Blood Bactericidal Activity Dose-Response Relationship, Immunologic Immunotherapy Mice Pseudomonas Aeruginosa Streptococcus Pneumoniae Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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