NDLI: Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol-binding protein.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1988 Volume: 85 Issue: 24

Year: 1988 Volume: 85 Issue: 23

Year: 1988 Volume: 85 Issue: 22

Year: 1988 Volume: 85 Issue: 21

Year: 1988 Volume: 85 Issue: 20

Year: 1988 Volume: 85 Issue: 19

Year: 1988 Volume: 85 Issue: 18

Year: 1988 Volume: 85 Issue: 17

Year: 1988 Volume: 85 Issue: 16

Year: 1988 Volume: 85 Issue: 15

Year: 1988 Volume: 85 Issue: 14

Year: 1988 Volume: 85 Issue: 13

Year: 1988 Volume: 85 Issue: 12

Year: 1988 Volume: 85 Issue: 11

Year: 1988 Volume: 85 Issue: 10

A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody.

Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels.

pp60c-src expression in the developing rat brain.

The alpha and beta chains of avian retrovirus reverse transcriptase independently expressed in Escherichia coli: characterization of enzymatic activities.

Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts.

Single-channel events and gating behavior of the cardiac gap junction channel.

Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

Molecular cloning of L-methylmalonyl-CoA mutase: gene transfer and analysis of mut cell lines.

The mouse surfeit locus contains a very tight cluster of four 'housekeeping' genes that is conserved through evolution.

Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA.

Single K+ channels activated by D2 dopamine receptors in acutely dissociated neurons from rat corpus striatum.

Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons.

Pertussis toxin-insensitive G protein mediates substance P-induced inhibition of potassium channels in brain neurons.

Calmodulin-dependent multifunctional protein kinase in Aspergillus nidulans.

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

Structural analysis of a series of antiviral agents complexed with human rhinovirus 14.

Isolation and characterization of natural allene oxides: unstable intermediates in the metabolism of lipid hydroperoxides.

Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

Potassium translocation by the Na+/K+ pump is voltage insensitive.

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

Thrombin modulates and reverses neuroblastoma neurite outgrowth.

Isolation of the gene encoding the Hin recombinational enhancer binding protein.

Production of a monoclonal antibody against the Snow Mountain agent of gastroenteritis by in vitro immunization of murine spleen cells.

Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.

Mechanochemical coupling in synthetic polypeptides by modulation of an inverse temperature transition.

Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin.

Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.

Molecular cloning of human T-cell lymphotrophic virus type I-like proviral genome from the peripheral lymphocyte DNA of a patient with chronic neurologic disorders.

Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice.

Mutation of aspartic acid-351, lysine-352, and lysine-515 alters the Ca2+ transport activity of the Ca2+-ATPase expressed in COS-1 cells.

Stabilization of an associated folding intermediate of bovine growth hormone by site-directed mutagenesis.

N,N'-dimethylthiourea dioxide formation from N,N'-dimethylthiourea reflects hydrogen peroxide concentrations in simple biological systems.

Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster.

Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM.

Evidence that DNA is present in abnormal tubulofilamentous structures found in scrapie.

Roles for chloride ion and fibrinogen in the activation of [Glu1]plasminogen in human plasma.

Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover.

A conserved sequence in the T-cell receptor beta-chain promoter region.

Identification of murine nuclear proteins that bind to the conserved octamer sequence of the immunoglobulin promoter region.

Toward an objective classification of cells in the immune system.

Cytopathic effect of human immunodeficiency virus in T4 cells is linked to the last stage of virus infection.

The cytoplasmic domain of Escherichia coli leader peptidase is a 'translocation poison' sequence.

A viral cleavage site cassette: identification of amino acid sequences required for tobacco etch virus polyprotein processing.

Saturation mutagenesis of a major histocompatibility complex protein domain: identification of a single conserved amino acid important for allorecognition.

Prognostic significance of 'short-term' effects of chemotherapy on MYC and histone H3 mRNA levels in acute leukemia patients.

Treponema pallidum invades intercellular junctions of endothelial cell monolayers.

Neural plasticity without postsynaptic action potentials: less-active inputs become dominant when kitten visual cortical cells are pharmacologically inhibited.

Further properties of random walks on diagrams (graphs) with and without cycles.

Separation of positional isomers of oligosaccharides and glycopeptides by high-performance anion-exchange chromatography with pulsed amperometric detection.

Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene.

Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.

Roles of a 67-kDa polypeptide in reversal of protein synthesis inhibition in heme-deficient reticulocyte lysate.

Immunodetection of estrogen receptor in epithelial and stromal tissues of neonatal mouse uterus.

Structural principles of parallel beta-barrels in proteins.

Cold denaturation of staphylococcal nuclease.

Cardiolipin from ethanol-fed rats confers tolerance to ethanol in liver mitochondrial membranes.

Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen.

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.

The 28-kDa calbindin-D is a major calcium-binding protein in the basilar papilla of the chick.

ATP-dependent association of nuclear proteins with isolated rat liver nuclei.

Induction of vitellogenin in primary monolayer cultures of cockerel hepatocytes.

Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol-binding protein.

Positional variations in germinal cell growth in pigment-chimeric eyes of Xenopus: posterior half of the developing eye studied in genetic chimerae and in computer simulations.

Identification of two structural types of calcium-dependent adhesion molecules in the chicken embryo.

Partial phylogeny of the unicellular eukaryotes based on rapid sequencing of a portion of 28S ribosomal RNA.

Gene sharing by delta-crystallin and argininosuccinate lyase.

Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family.

Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level.

HLA class II allelic variation and susceptibility to pemphigus vulgaris.

Time for acquiring a new gene by duplication.

Use of human peripheral blood lymphocytes to measure DNA binding capacity of chemical carcinogens.

Analysis of genetic variability and mapping of point mutations in influenza virus by the RNase A mismatch cleavage method.

Lack of complementation in somatic cell hybrids between fibroblasts from patients with different forms of cystinosis.

Influence of 5' flanking sequences on TL and H-2 expression in transfected L cells.

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

Cloning and characterization of a potentially protective antigen in lymphatic filariasis.

Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain.

Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat.

Bird song syntax: learned intraspecific variation is meaningful.

Year: 1988 Volume: 85 Issue: 9

Year: 1988 Volume: 85 Issue: 8

Year: 1988 Volume: 85 Issue: 7

Year: 1988 Volume: 85 Issue: 6

Year: 1988 Volume: 85 Issue: 5

Year: 1988 Volume: 85 Issue: 4

Year: 1988 Volume: 85 Issue: 3

Year: 1988 Volume: 85 Issue: 2

Year: 1988 Volume: 85 Issue: 1

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol-binding protein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Norum, K. R. Berg, T. Blomhoff, R.
Description	Author Affiliation: Blomhoff R ( Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.);
Abstract	Newly absorbed chylomicron remnant retinyl ester is endocytosed by parenchymal liver cells, and retinol is subsequently transferred to perisinusoidal stellate cells in liver. In the present study we have used several approaches to elucidate the mechanism for the paracrine transfer of retinol between liver parenchymal and stellate cells. In one series of experiments, chylomicrons labeled with [3H]retinyl palmitate or with retinyl [3H]palmitate were injected intravenously into rats. It was shown that the retinol as well as the palmitate moiety were initially taken up in parenchymal liver cells. However, only the retinol moiety was detected in stellate cells, indicating that the retinyl ester is hydrolyzed before retinol is transferred to stellate cells. It is well known that parenchymal liver cells secrete retinol bound to retinol-binding protein (RBP), and we have recently found that stellate cells do have RBP receptors. Here we report that antibodies against RBP completely block the transfer of retinol from parenchymal to stellate cells. These findings indicate that following uptake of chylomicron remnant retinyl ester in parenchymal cells, the retinyl ester is hydrolyzed, and retinol secreted from parenchymal cells on RBP is taken up by stellate cells by means of RBP receptors.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Liver Metabolism Retinol-Binding Proteins Vitamin A Animals Cell Communication Chylomicrons Kinetics Cytology Lymph Rats, Inbred Strains Analogs & Derivatives Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in