NDLI: Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

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Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

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Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lin, Y. S. Green, M. R.
Description	Author Affiliation: Lin YS ( Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.);
Abstract	We have previously identified a cellular transcription factor, ATF, which is involved in the expression of multiple adenovirus E1a-inducible genes. Here we show that ATF also binds to regulatory elements in cellular cAMP-inducible promoters. In these cellular promoters, ATF binds to a consensus sequence that has been previously shown to be necessary and in some instances sufficient for cAMP-inducible transcription. Furthermore, we show that binding of ATF to these promoter elements is required for the constitutive in vitro transcriptional activity of the cAMP-inducible somatostatin gene. Taken together, our results suggest that a common cellular transcription factor, ATF, can be regulated in vivo by two apparently unrelated inducing agents: the adenovirus E1a protein and cAMP.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenoviridae Genetics Blood Proteins Metabolism Cyclic AMP Pharmacology Genes, Regulator Genes, Viral Genes Oncogene Proteins, Viral Physiology Promoter Regions, Genetic Transcription Factors Activating Transcription Factors Adenovirus Early Proteins Antigens, Viral, Tumor Gene Expression Regulation Molecular Sequence Data Drug Effects Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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