NDLI: Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

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Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

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Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Von Hoff, D. D. Yucel, J. Windle, B. E. Wahl, G. M. Needham-vandevanter, D. R.
Description	Author Affiliation: Von Hoff DD ( Gene Expression Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138.);
Abstract	Amplification of genes can sometimes be detected by molecular hybridization but not by cytogenetic methods, suggesting that in some cases the units of amplification may be too small to be detected by light microscopy. The experiments reported here investigate whether submicroscopic amplification units are present in early passages of the human tumor cell lines HL-60 and COLO 320. The results show that such cells do contain submicroscopic, extrachromosomal, supercoiled circular molecules harboring MYC genes. The molecules in HL-60 are approximately 250 kilobase pairs (kbp), while those in COLO 320 are 120-160 kbp. The extrachromosomal molecules in HL-60 are shown to replicate semiconservatively and approximately once in one cell cycle. We propose that these submicroscopic elements are precursors of double-minute chromosomes, the usual extrachromosomal manifestation of gene amplification, since both are structurally similar and replicate autonomously.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Amplification Oncogenes Tumor Cells, Cultured Ultrastructure Animals Cell Line Colonic Neoplasms Pathology Cricetinae Cricetulus DNA Replication DNA, Circular Genetics Extrachromosomal Inheritance Leukemia, Myeloid, Acute Mesocricetus Replicon Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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