NDLI: Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1988 Volume: 85 Issue: 24

Year: 1988 Volume: 85 Issue: 23

Year: 1988 Volume: 85 Issue: 22

Year: 1988 Volume: 85 Issue: 21

Year: 1988 Volume: 85 Issue: 20

Year: 1988 Volume: 85 Issue: 19

Year: 1988 Volume: 85 Issue: 18

Year: 1988 Volume: 85 Issue: 17

Year: 1988 Volume: 85 Issue: 16

Year: 1988 Volume: 85 Issue: 15

Year: 1988 Volume: 85 Issue: 14

c-src gene product in developing rat brain is enriched in nerve growth cone membranes.

Molecular model for receptor-stimulated calcium spiking.

Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.

Toward a better understanding of protein folding pathways.

Quantitative analysis of RNA produced by slow and fast alleles of Adh in Drosophila melanogaster.

Adhesion domain of human T11 (CD2) is encoded by a single exon.

Interaction of an immunodominant epitope with Ia molecules in T-cell activation.

Properties of the ribosomal P2 protein autoantigen are similar to those of foreign protein antigens.

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

Human immunodeficiency virus type 1 challenge of chimpanzees immunized with recombinant envelope glycoprotein gp120.

Presence of antibodies to a putatively immunosuppressive part of human immunodeficiency virus (HIV) envelope glycoprotein gp41 is strongly associated with health among HIV-positive subjects.

Ion channels in synaptic vesicles from Torpedo electric organ.

Clone-forming ability and differentiation potential of migratory neural crest cells.

Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.

Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC.

Villin sequence and peptide map identify six homologous domains.

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides.

Orientation-dependent function of a short CYC1 DNA fragment in directing mRNA 3' end formation in yeast.

Molecular and biological interaction between major histocompatibility complex class I antigens and luteinizing hormone receptors or beta-adrenergic receptors triggers cellular response in mice.

Insulin stimulates glyceraldehyde-3-phosphate dehydrogenase gene expression through cis-acting DNA sequences.

Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1.

Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA.

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes.

Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma.

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.

Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta.

Single base mutation in the pro alpha 2(I) collagen gene that causes efficient splicing of RNA from exon 27 to exon 29 and synthesis of a shortened but in-frame pro alpha 2(I) chain.

Alterations of amino acid repeats in the Escherichia coli hemolysin affect cytolytic activity and secretion.

Induction of nerve growth factor receptors on cultured human melanocytes.

Characterization and cloning of fasciclin I and fasciclin II glycoproteins in the grasshopper.

Activation of type B gamma-aminobutyric acid receptors in the intact mammalian spinal cord mimics the effects of reduced presynaptic Ca2+ influx.

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.

Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells.

Molecular evidence for somatic recombination in the ribosomal DNA of Tetrahymena thermophila.

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

L-glutamate-induced depolarization in solitary photoreceptors: a process that may contribute to the interaction between photoreceptors in situ.

Efficacy of a cell-mediated reaction to the purified protein derivative of tuberculin in the disposal of Mycobacterium leprae from human skin.

Tissue-specific expression and cDNA cloning of small nuclear ribonucleoprotein-associated polypeptide N.

Structural fluctuations of a helical polypeptide traversing a lipid bilayer.

Electrostatic complementarity within the substrate-binding pocket of trypsin.

Active site-directed inhibition of Ca2+/calmodulin-dependent protein kinase type II by a bifunctional calmodulin-binding peptide.

Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.

Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.

Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

Secondary structure of complement component C3a anaphylatoxin in solution as determined by NMR spectroscopy: differences between crystal and solution conformations.

Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice.

Transmitter and receiver modules in bacterial signaling proteins.

Purification of ras GTPase activating protein from bovine brain.

Bypass and termination at apurinic sites during replication of single-stranded DNA in vitro: a model for apurinic site mutagenesis.

T24 human bladder carcinoma cells with activated Ha-ras protooncogene: nontumorigenic cells susceptible to malignant transformation with carcinogen.

Comparative evolution: latent potentials for anagenetic advance.

Identification of two integral membrane proteins of Plasmodium falciparum.

Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes.

Lateral geniculate lesions block circadian phase-shift responses to a benzodiazepine.

Catalysis of concerted reactions by antibodies: the Claisen rearrangement.

Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain.

Differential distribution of D and L amino acids between the 2' and 3' positions of the AMP residue at the 3' terminus of transfer ribonucleic acid.

Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains.

A transcription factor active on the epidermal growth factor receptor gene.

Monte Carlo simulations of the folding of beta-barrel globular proteins.

Iron-carbonyl bond geometries of carboxymyoglobin and carboxyhemoglobin in solution determined by picosecond time-resolved infrared spectroscopy.

Canonical formulation of linkage thermodynamics.

K+ efflux in NIH mouse 3T3 cells and transformed derivatives: dependence on extracellular Ca2+ and phorbol esters.

Human skin fibroblasts in vitro differentiate along a terminal cell lineage.

Structure of a fish (rainbow trout) growth hormone gene and its evolutionary implications.

Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia.

Photophysical studies of tin(IV)-protoporphyrin: potential phototoxicity of a chemotherapeutic agent proposed for the prevention of neonatal jaundice.

Lesion-induced plasticity in the second somatosensory cortex of adult macaques.

Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus.

Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.

6-Acetylmorphine: a natural product present in mammalian brain.

Year: 1988 Volume: 85 Issue: 13

Year: 1988 Volume: 85 Issue: 12

Year: 1988 Volume: 85 Issue: 11

Year: 1988 Volume: 85 Issue: 10

Year: 1988 Volume: 85 Issue: 9

Year: 1988 Volume: 85 Issue: 8

Year: 1988 Volume: 85 Issue: 7

Year: 1988 Volume: 85 Issue: 6

Year: 1988 Volume: 85 Issue: 5

Year: 1988 Volume: 85 Issue: 4

Year: 1988 Volume: 85 Issue: 3

Year: 1988 Volume: 85 Issue: 2

Year: 1988 Volume: 85 Issue: 1

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kazazis, D. M. Singer, I. I. Huff, J. W. Scott, S.
Description	Author Affiliation: Singer II ( Department of Biochemical and Molecular Pathology, Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065.);
Abstract	Lovastatin is a potent competitive inhibitor of the rate-limiting enzyme of cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (NADPH) [HMG-CoA reductase; (S)-mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1.1.34]. We determined the subcellular distribution of HMG-CoA reductase at high resolution by means of immunoelectron microscopy on ultrathin frozen liver sections of rats treated with lovastatin and cholestyramine. High concentrations of reductase were located on the outer (cytoplasmic) surfaces of smooth endoplasmic reticulum (SER) membranes induced in hepatocytes by acute drug administration. The enzyme was specifically localized over the whorled SER membranes and was absent from nonwhorled SER, rough endoplasmic reticulum, and peroxisomes. Intense HMG-CoA reductase labeling was only observed in hepatocytes containing high levels of HMG-CoA reductase activity; no staining was detected in untreated livers. These observations show that HMG-CoA reductase is induced as an integral component of the SER membranes that form in rat hepatocytes subsequent to lovastatin treatment and suggest that the formation of SER whorls in rat hepatocytes is due to mechanism-based effects of lovastatin.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Endoplasmic Reticulum Enzymology Hydroxymethylglutaryl CoA Reductases Biosynthesis Liver Lovastatin Pharmacology Animals Cholestyramine Resin Enzyme Induction Drug Effects Fluorescent Antibody Technique Hydroxymethylglutaryl-CoA Reductase Inhibitors Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent Immunohistochemistry Microscopy, Electron Rats, Inbred Strains Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in