NDLI: Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

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Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

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Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Allen, P. M. Lorenz, R. G.
Description	Author Affiliation: Lorenz RG ( Department of Pathology, Washington University School of Medicine, Saint Louis, MO 63110.);
Abstract	Through the development of a panel of murine hybridomas reactive to murine hemoglobin, we have been able to study the processing and presentation of self antigens by antigen-presenting cells. Our results demonstrate that peritoneal macrophages in vivo can process and potentially present the self-antigen hemoglobin. We have extended this finding to show that, directly after removal from the mouse, antigen-presenting cells from a variety of tissues stimulate our hemoglobin-specific hybridomas without any manipulation or addition of exogenous antigen. This constitutes direct functional proof that in a nondisease state self proteins are processed constitutively and can be presented in a fashion similar to that in which foreign antigens are presented. Our demonstration that antigen-presenting cells can process and potentially present self as well as foreign molecules implies that self-tolerance occurs at the level of the T cell. This constitutive processing and presentation of self antigens has potentially far-reaching implications in self-tolerance, autoimmunity, and alloreactivity.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigen-Presenting Cells Immunology Autoantigens Hemoglobins Histocompatibility Antigens Class II Amino Acid Sequence Animals Globins Hybridomas Immunization Macrophages Mice Mice, Inbred CBA Molecular Sequence Data Peritoneal Cavity Cytology T-Lymphocytes Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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