NDLI: Immunotitration of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in various physiological states.

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Immunotitration of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in various physiological states.

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Immunotitration of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in various physiological states.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Heller, R. A. Herrera, M. G. Scallen, T. J. Hardgrave, J. E.
Abstract	The immunotitration of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [mevalonate:NADP+ oxidoreductase [CoA-acylating), EC 1.1.1.34], the major regulatory enzyme in cholesterol biosynthesis, by HMG-CoA reductase antiserum is described. This technique provides the advantage that one can rapidly measure relative changes in both enzyme concentration and enzyme activity in different physiological states by using enzyme samples all the way from crude liver microsomes to purified enzyme. Regarding the diurnal rhythm of HMG-CoA reductase, the major difference noted between animals killed near the middle of the dark period (D 4.5) compared to animals killed near the middle of the light period (L 4.5) was in the concentrations of HMG-CoA reductase present, rather than in the activity of the enzyme, with substantially more enzyme found near mid-dark. Cholestyramine treatment resulted in both an increased concentration of HMG-CoA reductase and a catalytically more active enzyme. On the other hand, cholesterol feeding resulted in both a decreased concentration of HMG-CoA reductase and a catalytically less active enzyme.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hydroxymethylglutaryl CoA Reductases Metabolism Microsomes, Liver Enzymology Animals Cholesterol Pharmacology Cholestyramine Resin Circadian Rhythm Immunology Immunologic Techniques Liver Drug Effects Physiology Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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