NDLI: Ia-antigen-T-cell interactions for a thymus-independent antigen composed of D amino acids.

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Ia-antigen-T-cell interactions for a thymus-independent antigen composed of D amino acids.

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Ia-antigen-T-cell interactions for a thymus-independent antigen composed of D amino acids.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zisman, E. Sela, M. Mozes, E. Dayan, M.
Description	Author Affiliation: Zisman E ( Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.);
Abstract	Synthetic polypeptide antigens of L amino acids, although bearing repeating sequences, are thymus-dependent (L-TD), whereas the same polymers composed of D amino acids are thymus-independent (D-TI), probably due to a slower rate of metabolism. Yet we found that lymph-node cells of BALB/c mice immunized with D-TI proliferate in response to it in vitro. To follow T-cell activation by D-TI, we established T-cell hybridomas to D-TI and to its analog composed of L isomers, L-TD, for comparison. The T-cell hybridomas express membrane alpha/beta T-cell receptors and secrete interleukin 2 upon stimulation with the respective antigen. In addition, D-TI-specific hybridomas are stimulated, to a lesser extent, by the L-TD antigen, whereas only some L-TD-specific hybridomas recognize D-TI. Moreover, biotinylated analogs of D-TI and L-TD bind to splenic antigen-presenting cells (APCs) from BALB/c mice. Binding is inhibited by an excess of nonbiotinylated L-TD, and by an excess of a peptide comprising residues 259-271 of the human acetylcholine receptor alpha subunit, which binds to I-Ad and I-Ed molecules without prior processing. Analysis of APC lysates following incubation of the APCs with biotinylated D-TI and L-TD reveals that the biotinylated antigen moiety is associated with Ia molecules. D-TI and L-TD bind to Ia molecules on intact APCs with similar KD values, 5 x 10(-8) M and 3 x 10(-8) M, respectively. However, D-TI has faster kinetics of binding than L-TD, probably due to different processing requirements. Hence, we have demonstrated a major histocompatibility complex class II-mediated T-cell response to a thymus-independent antigen.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amino Acids Immunology Antigens, T-Independent Histocompatibility Antigens Class II Hybridomas T-Lymphocytes Animals Antigen-Presenting Cells Lymph Nodes Lymphocyte Activation Mice Mice, Inbred AKR Mice, Inbred BALB C Spleen Stereoisomerism Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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