NDLI: B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

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B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

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B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tsang, S. Y. Peterlin, B. M. Nakanishi, M.
Description	Author Affiliation: Tsang SY ( Howard Hughes Medical Institute, University of California, San Francisco 94143.);
Abstract	We investigated the cis-acting sequences that function in the B-cell-specific and interferon-gamma-inducible expression of the HLA-DR alpha gene, a human class II major histocompatibility complex gene. The effects of 5' deletions on the activity of the DR alpha promoter and the influence of upstream DR alpha promoter elements on the activity of the herpes simplex virus thymidine kinase promoter were examined by a transient transfection assay in human B-, T-, and fibroblast cell lines. We show that the DR alpha gene is regulated by positive and negative cis-acting sequences between positions -1300 and +31 from the site of initiation of transcription. We also demonstrate that the DR alpha promoter sequences from positions -116 to -92 and from -136 to -80 are the minimal sequences required for conferring B-cell specificity and interferon-gamma inducibility upon the Herpes simplex virus thymidine kinase promoter, respectively.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology Gene Expression Regulation Genes, MHC Class II HLA-DR Antigens Genetics Interferon-gamma Cell Line Chromosome Deletion Molecular Sequence Data Plasmids Promoter Regions, Genetic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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