NDLI: Characterization and expression of the murine CD3-epsilon gene.

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Characterization and expression of the murine CD3-epsilon gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wileman, T. Clevers, H. Terhorst, C. Dunlap, S. Saito, H. Georgopoulos, K.
Description	Author Affiliation: Clevers H ( Laboratory of Molecular Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.);
Abstract	The receptor for antigen on the surface of T lymphocytes consists of a variable disulfide-bridged hetero-dimer (TCR-alpha/beta or -gamma/delta) associated with invariant CD3 proteins (CD3-gamma, -delta, -epsilon, and -zeta). The genes coding for the CD3 proteins are expressed in the earliest recognizable thymocytes, preceding the rearrangement and expression of the TCR genes. The isolation, characterization, and in vitro expression of the murine CD3-epsilon gene, as reported here, represent obligatory steps toward our understanding of the complex rules that govern T-cell-specific gene expression. The CD3-epsilon gene was transcribed from a non-TATA promoter and consisted of eight exons, two of which were unusually small (18 and 15 base pairs). The transmembrane exon was found to be homologous to the transmembrane exons of the CD3-gamma and CD3-delta genes. In transient-transfection experiments, a genomic fragment comprising 4 kilobases of upstream sequence and extending into the second exon sufficient to drive the expression of a reporter gene in murine T cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Differentiation, T-Lymphocyte Genetics Genes Receptors, Antigen, T-Cell Amino Acid Sequence Animals Antigens, CD3 Cloning, Molecular DNA Isolation & Purification Genes, Immunoglobulin Mice Molecular Sequence Data Restriction Mapping Sequence Homology, Nucleic Acid Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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