NDLI: Addition of a foreign oligopeptide to the major capsid protein of poliovirus.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1988 Volume: 85 Issue: 24

Year: 1988 Volume: 85 Issue: 23

Year: 1988 Volume: 85 Issue: 22

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching.

Immunobiologic differences between normal and leukemic human B-cell precursors.

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T cells from an HIV-1-infected individual.

Stochastic development of invasive potential in rat mammary tumors induced by N-methyl-N-nitrosourea.

Addition of a foreign oligopeptide to the major capsid protein of poliovirus.

M2 delta, a candidate for the structure lining the ionic channel of the nicotinic cholinergic receptor.

Expression of diphtheria toxin fragment A and hormone-toxin fusion proteins in toxin-resistant yeast mutants.

Regulation of beta-adrenergic receptors by 'permissive' hormones: glucocorticoids increase steady-state levels of receptor mRNA.

Receptor interactions through phosphorylation and methylation pathways in bacterial chemotaxis.

cDNA sequence of rat liver fructose-1,6-bisphosphatase and evidence for down-regulation of its mRNA by insulin.

Properties of two 5'-coterminal RNAs transcribed part way and across the S component origin of DNA synthesis of the herpes simplex virus 1 genome.

In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

A lamin B receptor in the nuclear envelope.

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

Mutant gene phenotypes mediated by a Drosophila melanogaster retrotransposon require sequences homologous to mammalian enhancers.

Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line.

Biochemical localization of hepatic surface-membrane Na+,K+-ATPase activity depends on membrane lipid fluidity.

Oligomeric structure of a prototype retrovirus glycoprotein.

Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation: implications for sites of viral latency.

Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.

Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs.

Site of covalent attachment of alpha-scorpion toxin derivatives in domain I of the sodium channel alpha subunit.

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.

Alpha 1-adrenergic agonists selectively suppress voltage-dependent K+ current in rat ventricular myocytes.

Localization of chitin synthetase in cell-free homogenates of Saccharomyces cerevisiae: chitosomes and plasma membrane.

Characterization and expression of the murine CD3-epsilon gene.

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.

DNA methylation prevents transfection of genes for specific surface antigens.

Nucleotide sequence of the genetic loci encoding subunits of Bradyrhizobium japonicum uptake hydrogenase.

Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor.

Repair of 4,5',8-trimethylpsoralen monoadducts and cross-links by the Escherichia coli UvrABC endonuclease.

Structure of the reaction center from Rhodobacter sphaeroides R-26: protein-cofactor (quinones and Fe2+) interactions.

Secretion of functional antibody and Fab fragment from yeast cells.

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a 'zinc finger-like' protein sequence.

cDNA-derived sequence of chicken embryo vinculin.

B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection.

A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.

Acidic intracellular pH shift during Caenorhabditis elegans larval development.

Cloning and sequence analysis of cDNA for corticotropin-releasing factor precursor from the teleost fish Catostomus commersoni.

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

Induction of protooncogene c-jun by serum growth factors.

Allosteric equilibria in the binding of fibrinogen to platelets.

Statistical effects in the absorption and optical activity of particulate suspensions.

Orientation of carbon monoxide and structure-function relationship in carbonmonoxymyoglobin.

Ligand binding to synthetic mutant myoglobin (His-E7----Gly): role of the distal histidine.

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.

Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT).

Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.

High level of accumulation of a mRNA coding for a precursor-like protein in the submaxillary gland of male rats.

Role of the overdrive sequence in T-DNA border cleavage in Agrobacterium.

Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.

A genomic DNA segment from Petunia hybrida leads to increased transformation frequencies and simple integration patterns.

Intramolecular recombination of chloroplast genome mediated by short direct-repeat sequences in wheat species.

Targeted mutation of the Hprt gene in mouse embryonic stem cells.

Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen.

Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.

Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa.

Synergism at central synapses due to lateral diffusion of transmitter.

Control of Torpedo acetylcholine receptor biosynthesis in Xenopus oocytes.

Birth of projection neurons in the higher vocal center of the canary forebrain before, during, and after song learning.

Honeybee retinal glial cells transform glucose and supply the neurons with metabolic substrate.

Magnetic localization of neuronal activity in the human brain.

Ex vivo model of an immobilized-enzyme reactor.

Cadmium accelerates bone loss in ovariectomized mice and fetal rat limb bones in culture.

Amine cations promote concurrent conversion of prohistidine decarboxylase from Lactobacillus 30a to active enzyme and a modified proenzyme.

At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.

Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

Identification of arginine as a precursor of endothelium-derived relaxing factor.

Year: 1988 Volume: 85 Issue: 21

Year: 1988 Volume: 85 Issue: 20

Year: 1988 Volume: 85 Issue: 19

Year: 1988 Volume: 85 Issue: 18

Year: 1988 Volume: 85 Issue: 17

Year: 1988 Volume: 85 Issue: 16

Year: 1988 Volume: 85 Issue: 15

Year: 1988 Volume: 85 Issue: 14

Year: 1988 Volume: 85 Issue: 13

Year: 1988 Volume: 85 Issue: 12

Year: 1988 Volume: 85 Issue: 11

Year: 1988 Volume: 85 Issue: 10

Year: 1988 Volume: 85 Issue: 9

Year: 1988 Volume: 85 Issue: 8

Year: 1988 Volume: 85 Issue: 7

Year: 1988 Volume: 85 Issue: 6

Year: 1988 Volume: 85 Issue: 5

Year: 1988 Volume: 85 Issue: 4

Year: 1988 Volume: 85 Issue: 3

Year: 1988 Volume: 85 Issue: 2

Year: 1988 Volume: 85 Issue: 1

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Addition of a foreign oligopeptide to the major capsid protein of poliovirus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Garapin, A. C. Colbère-garapin, F. Crainic, R. Candrea, A. Christodoulou, C.
Description	Author Affiliation: Colbère-Garapin F ( Unité de Virologie Médicale, Institut Pasteur, Paris, France.);
Abstract	Insertion mutants of type 3 poliovirus (Sabin strain) were constructed that encode additional amino acid sequences at the level of residue 100 of the capsid polypeptide VP1 within the neutralization site 1, corresponding to a loop on the capsid surface. The addition of a tri- or hexapeptide did not hamper virus viability. The antigenic pattern of insertion mutants was only modified locally: all mutants lost reactivity of neutralization site 1 with the corresponding monoclonal antibodies, while the reactivity of sites 2 and 3 was unaffected by the insertion. We have shown for one of the mutants--vFG68--that the antigenic specificity of the neutralization site 1 was replaced by a new one. Although vFG68 differs from its parental Sabin strain only by the addition of three amino acids within VP1, neutralizing antibodies specific for vFG68 were induced by the native virion as well as by the heat-denatured mutated virions. Our results demonstrate that an oligopeptide of three or six amino acids can lengthen VP1 at the level of antigenic site 1 without affecting virus multiplication and that this foreign peptide is exposed on the virion surface.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Capsid Genetics DNA Transposable Elements Mutation Oligopeptides Poliovirus Amino Acid Sequence Immunology Codon Epitopes Escherichia Coli Molecular Sequence Data Plasmids Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in