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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shackelford, D. A. Johnson, P. Hyman, R. Trowbridge, I. S. Ostergaard, H. L. Sefton, B. M. Hurley, T. R. |
| Description | Author Affiliation: Ostergaard HL ( Department of Cancer Biology, Salk Institute, San Diego, CA 92138.); |
| Abstract | CD45 is a family of high molecular weight leukocyte cell surface glycoproteins. Recently, two related subregions of the cytoplasmic domain of CD45 have been shown to have 30-40% amino acid identity with a human placental protein phosphotyrosine phosphatase, and CD45 isolated from human spleen was found to exhibit intrinsic protein phosphotyrosine phosphatase (EC 3.1.3.48) activity. In the present studies, we demonstrate that each of the known isoforms of murine CD45 has an equivalent basal level of protein phosphotyrosine phosphatase activity and establish that this enzymatic activity is associated with the cytoplasmic domain of the glycoprotein. Studies with three independent sets of well-characterized parental CD45+, mutant CD45-, and revertant CD45+ lymphoma cell lines indicate that loss of CD45 increases the phosphorylation of the src-related leukocyte-specific tyrosine protein kinase p56lck on tyrosine-505, a putative negative regulatory site. This suggests that CD45 may play a role in leukocyte growth regulation by altering the kinase activity of p56lck. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 22 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Differentiation Genetics Gene Expression Histocompatibility Antigens Membrane Glycoproteins Protein-Tyrosine Kinases Animals Antigens, CD45 Immunology Cell Line Immunoblotting Kinetics Lymphocyte Activation Lymphoma Enzymology Mice Mutation Peptide Fragments Isolation & Purification Phosphorylation Metabolism T-Lymphocytes Trypsin Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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