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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nathans, D. Christy, B. |
| Description | Author Affiliation: Christy B ( Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.); |
| Abstract | Zif268, a zinc finger protein whose mRNA is rapidly activated in cells exposed to growth factors or other signaling agents, is thought to play a role in regulating the genetic program induced by extracellular ligands. We report that Zif268 has one of the characteristics of a transcriptional regulator, namely, sequence-specific binding to DNA. Zif268 synthesized in Escherichia coli bound to two sites upstream of the zif268 gene and to sites in the promoter regions of other genes. The nucleotide sequences responsible for binding were defined by DNase I footprinting, by methylation interference experiments, and by use of synthetic oligonucleotides. From these results we derived the following consensus sequence for a Zif268 high-affinity binding site: GCGTGGGGCG. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 22 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA-Binding Proteins Metabolism DNA Growth Substances Pharmacology Metalloproteins Transcription Factors Zinc Binding Sites Binding, Competitive Cloning, Molecular Biosynthesis Genetics Deoxyribonuclease I Escherichia Coli Gene Expression Regulation Molecular Sequence Data Protein Biosynthesis Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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